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Table 3 Stepwise regression analysis for pre-existing diabetic dialysis patients with 5-year survival rate, n = 2956

From: Effect of anti-diabetic drugs in dialysis patients with diabetes: a nationwide retrospective cohort study

Variables

Univariate

Multivariate

HR (95% CI)

P-value

aHR (95% CI)

P-value

Age > 60 year

2.31 (2.01–2.65)

 < 0.001

2.05 (1.78–2.35)

 < 0.001

Gender—male

1.09 (0.96–1.24)

0.183

  

Anti-diabetic drug use

 Non-user

1

 

1

 

 OHA

0.44 (0.37–0.53)

 < 0.001

0.56 (0.49–0.68)

 < 0.001

 Insulin

0.52 (0.43–0.63)

 < 0.001

0.66 (0.55–0.80)

 < 0.001

Region

 Northern

1

   

 Central

1.01 (0.86–1.19)

0.900

  

 Southern/Eastern

0.94 (0.81–1.09)

0.398

  

Insured premium (NT$)

 < 15,840

1

   

 15,840–25,000

0.87 (0.75–1.02)

0.084

  

 > 25,000

0.80 (0.68–0.95)

0.012

  

Urbanization

 Urban

1

   

 Sub-urban

1.09 (0.95–1.25)

0.236

  

 Rural

1.10 (0.90–1.33)

0.365

  

Hospital characteristics

 Medical center

1.03 (0.89–1.19)

0.674

  

 Region/others

1

   

Number of admissions during the 12 months leading up to dialysis

 0–1

1

 

1

 

 > 1

1.72 (1.51–1.95)

 < 0.001

1.59 (1.38–1.83)

 < 0.001

Dialysis modality

 Peritoneal dialysis

1

   

 Hemodialysis

0.86 (0.64–1.15)

0.306

  

Comorbidity

 Hypertension

1.14 (0.98–1.31)

0.070

0.73 (0.67–0.91)

0.002

 Hyperlipidemia

0.80 (0.69–0.93)

0.003

  

 Gout

1.07 (0.86–1.32)

0.562

  

 Congestive heart failure

1.22 (1.07–1.39)

0.003

  

 Cerebrovascular accident

1.35 (1.16–1.57)

 < 0.001

1.21 (1.03–1.41)

0.020

 COPD

1.57 (1.27–1.64)

 < 0.001

1.21 (0.98–1.49)

0.087

 Chronic liver disease

1.65 (1.32–2.07)

 < 0.001

1.48 (1.18–1.86)

0.001

 Malignancy

1.65 (1.36–2.01)

 < 0.001

1.24 (1.01–1.52)

0.037

ACEI/ARB use

0.59 (0.52–0.67)

 < 0.001

0.56 (0.47–0.68)

 < 0.001

Lipid-lowering drug use

0.50 (0.43–0.58)

 < 0.001

0.66 (0.55–0.80)

 < 0.001

  1. HR hazard ratio, CI confidence interval, aHR adjusted hazard ratio, OHA oral hypoglycemia agents, COPD chronic obstructive pulmonary disease, ACEI angiotensin converting enzyme inhibitors, ARB angiotensin II receptor blockers