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Table 2 Stepwise regression analysis for all dialysis patients with 5-year survival rate, n = 5249

From: Effect of anti-diabetic drugs in dialysis patients with diabetes: a nationwide retrospective cohort study

Variables

Univariate

Multivariate

HR (95% CI)

P-value

aHR (95% CI)

P-value

Age > 60 year

2.74 (2.45–3.07)

 < 0.001

2.32 (2.08–2.61)

 < 0.001

Gender—male

1.06 (0.96–1.18)

0.273

1.00 (0.95–1.05)

0.984

Grouping

 NDD

1

 

1

 

 IDD

1.23 (1.09–1.37)

 < 0.001

1.35 (1.20–1.52)

 < 0.001

 PDD-M

1.46 (1.19–1.78)

 < 0.001

1.52 (1.25–1.86)

 < 0.001

 PDD-NM

2.58 (2.16–3.07)

 < 0.001

2.12 (1.77–2.53)

 < 0.001

Region

 Northern

1

   

 Central

1.08 (0.95–1.22)

0.231

  

 Southern/Eastern

0.92 (0.82–1.03)

0.153

  

Insured premium (NT$)

 < 15,840

1

 

1

 

 15,840–25,000

0.84 (0.74–0.94)

0.003

0.86 (0.75–0.96)

0.010

 > 25,000

0.72 (0.63–0.82)

 < 0.001

0.85 (0.74–0.97)

0.014

Urbanization

 Urban

1

   

 Sub-urban

1.11 (0.99–1.24)

0.067

  

 Rural

1.23 (1.05–1.43)

0.008

  

Hospital characteristics

 Medical center

1

   

 Region/others

1.01 (0.91 -1.13)

0.836

  

Number of admissions during the 12 months leading up to dialysis

 0–1

1

 

1

 

 > 1

1.87 (1.69–2.07)

 < 0.001

1.60 (1.42–1.80)

 < 0.001

Dialysis modality

 Peritoneal dialysis

1

   

 Hemodialysis

1.76 (1.40–2.22)

 < 0.001

  

Comorbidity

 Hypertension

1.22 (1.10–1.36)

 < 0.001

0.78 (0.69–0.88)

 < 0.001

 Hyperlipidemia

0.78 (0.69–0.88)

 < 0.001

  

 Gout

0.91 (0.78–1.07)

0.251

  

 Congestive heart failure

1.37 (1.23–1.52)

 < 0.001

1.15 (1.03–1.28)

0.012

 Cerebrovascular accident

1.51 (1.33–1.71)

 < 0.001

1.26 (1.11–1.43)

0.001

 COPD

1.84 (1.58–2.14)

 < 0.001

1.34 (1.14–1.56)

 < 0.001

 Chronic liver disease

1.57 (1.30–1.90)

 < 0.001

1.36 (1.12–1.66)

0.002

 Malignancy

1.81 (1.57–2.09)

 < 0.001

1.39 (1.20–1.61)

 < 0.001

ACEI/ARB use

0.58 (0.52–0.64)

 < 0.001

0.68 (0.62–0.76)

 < 0.001

Lipid-lowering drug use

0.50 (0.44–0.57)

 < 0.001

0.61 (0.54–0.69)

 < 0.001

  1. HR hazard ratio, CI confidence interval, aHR adjusted hazard ratio, NDD non-diabetic dialysis, IDD incident diabetes after dialysis, PDD-NM pre-existing diabetes dialysis patients not continuing medication, PDD-M pre-existing diabetes dialysis patients continuing medication, COPD chronic obstructive pulmonary disease, ACEI angiotensin converting enzyme inhibitors, ARB angiotensin II receptor blockers