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Table 3 Unadjusted and adjusted hazard ratio of the association of sex with cardiovascular mortalitya stratified by type 2 diabetes mellitus status (n = 7443)

From: Association of sex-specific differences in lipoprotein(a) concentrations with cardiovascular mortality in individuals with type 2 diabetes mellitus

 

No type 2 diabetes mellitus (n = 6988)

Type 2 diabetes mellitus (n = 455)

Hazard ratio (95%-CI)

p-value

Hazard ratio (95%-CI)

p-value

Model 1

 Men versus women

1.88 (1.58; 2.24)

< 0.001

1.28 (0.89; 1.83)

0.178

Model 2

 Men versus women

1.84 (1.54; 2.20)

< 0.001

1.36 (0.94; 1.97)

0.107

 Age (years)

1.15 (1.14; 1.17)

< 0.001

1.12 (1.09; 1.15)

< 0.001

 Body mass index (kg/m2)

1.06 (1.04; 1.08)

< 0.001

1.00 (0.96; 1.04)

0.934

 Low-density lipoprotein cholesterol (mmol/L)

1.02 (0.94; 1.12)

0.599

1.05 (0.86; 1.28)

0.623

 Fasting status

1.23 (0.83; 1.81)

0.306

1.50 (0.45; 4.98)

0.503

 Hypertension

1.59 (1.28; 1.97)

< 0.001

1.59 (0.92; 2.76)

0.097

 Smoking

2.10 (1.66; 2.65)

< 0.001

2.21 (1.31; 3.73)

0.003

Model 3

 Men versus women

1.84 (1.54; 2.20)

< 0.001

1.48 (1.01; 2.18)

0.034

 Age (years)

1.15 (1.14; 1.17)

< 0.001

1.12 (1.09; 1.16)

< 0.001

 Body mass index (kg/m2)

1.06 (1.04; 1.08)

< 0.001

1.01 (0.96; 1.05)

0.782

 Low-density lipoprotein cholesterol (mmol/L)

1.02 (0.93; 1.11)

0.697

1.04 (0.85; 1.27)

0.691

 Fasting status

1.22 (0.83; 1.80)

0.318

1.61 (0.49; 5.33)

0.433

 Hypertension

1.59 (1.28; 1.98)

< 0.001

1.62 (0.94; 2.81)

0.083

 Smoking

2.10 (1.66; 2.65)

< 0.001

2.28 (1.35; 3.84)

0.002

 Lipoprotein(a) (100 mg/L)

1.01 (0.98; 1.05)

0.482

1.07 (1.02; 1.13)

0.006

  1. Data are reported as Hazard Ratios (95% confidence intervals [CI]) and p-values derived from Cox regression models. All models (including model 1) were also adjusted for study sample
  2. aCardiovascular mortality = ICD-10 codes: I10 to I79 and R99 in SHIP-0 and I10 to I99 in MONICA/KORA S3