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Table 1 Clinical characteristics of patients with type 2 diabetes mellitus (T2DM) treated with SGLT2i

From: The risk of consequent nephropathy following initial weight loss in diabetic patients treated with sodium glucose cotransporter 2 inhibitors

 

Patient enrollment (n = 8992)

Clinical characteristics

 Diabetes duration (year)

8.6 ± 3.4

 Age (year)

58.8 ± 11.3

 Female

3864 (43)

 Ischemic heart etiology

633 (7)

 Hypertension

6032 (67)

 Dyslipidemia

7026 (78)

 Cerebral vascular accidents

361 (4)

 Congestive heart failure

291 (3)

 Peripheral artery disease

74 (1)

 Gout

924 (10)

 Malignancy

734 (8)

Baseline body weight (BW) and BW change

 Baseline body weight (kg)

74.0 ± 15.1

 Baseline BMI (kg/m2)

27.9 ± 4.7

 Body weight change (kg)

− 1.24 ± 2.83

 Body weight change (%)

− 1.65 ± 3.84

Baseline laboratory data

 HbA1c (%)

8.9 ± 1.6

 eGFR (ml/min/1.73 m2)

93.3 ± 22.0

 Triglycerides (mg/dL)

180.3 ± 204.7

 LDL (mg/dL)

92.5 ± 29.7

 HDL (mg/dL)

43.9 ± 11.2

 Uric acid (mg/dL)

5.7 ± 1.4

 Urine ACR (mg/g)

236.9 ± 787.8

Baseline medications

 Anti-platelet agent

2809 (31)

 Statin

5703 (63)

 ACEI or ARB

5371 (60)

 Use of diuretics

787 (9)

Anti-diabetic agent

 

 SU

6203 (69)

 Metformin

8229 (92)

 Glinide

297 (3)

 DPP4i

4564 (51)

 Glitazone

2340 (26)

 Acarbose

1955 (22)

 Insulin

1736 (19)

 GLP1 agonist

84 (1)

  1. Data are expressed as mean ± standard deviation or number (%)
  2. ACEI angiotensin-converting enzyme inhibitor, ACR albumin to creatinine ratio, ARB angiotensin receptor blocker, BMI body mass index, DPP4i dipeptidyl peptidase-4 inhibitor, eGFR estimated glomerular filtration rate, GLP1 glucagon-like peptide 1, HBA1c hemoglobin A1c, HDL high-density lipoprotein, LDL low-density lipoprotein, SGLT2i sodium–glucose co-transporter-2 inhibitor, SU sulfonylurea