Table 2 Hazard ratios for each of the assessed outcome considering the entire cohort and separately males/females, along with the p for trend among quartiles for each outcome and the relative p for interaction for the sex-based subgroup analysis

Primary Composite Outcome

vikt_STD_Q2

1.08 (1.03–1.12)

0.0012

1.11 (1.05–1.18)

0.0005

1.03 (0.97–1.11)

0.3152

0.539

vikt_STD_Q3

1.18 (1.13–1.24)

 < .0001

1.20 (1.13–1.28)

 < .0001

1.16 (1.08–1.24)

 < .0001

vikt_STD_Q4

1.45 (1.39–1.52)

 < .0001

1.46 (1.37–1.55)

 < .0001

1.46 (1.36–1.56)

 < .0001

Expanded Composite Outcome

vikt_STD_Q2

1.06 (1.02–1.11)

0.0057

1.08 (1.02–1.15)

0.0050

1.03 (0.97–1.10)

0.3296

0.823

vikt_STD_Q3

1.16 (1.11–1.21)

 < .0001

1.16 (1.10–1.23)

 < .0001

1.15 (1.08–1.23)

 < .0001

vikt_STD_Q4

1.41 (1.35–1.47)

 < .0001

1.39 (1.31–1.48)

 < .0001

1.43 (1.34–1.53)

 < .0001

All cause mortality

vikt_STD_Q2

1.10 (1.05–1.16)

0.0003

1.12 (1.05–1.21)

0.0015

1.08 (1.00–1.17)

0.0393

0.527

vikt_STD_Q3

1.27 (1.21–1.34)

 < .0001

1.31 (1.21–1.41)

 < .0001

1.23 (1.14–1.33)

 < .0001

vikt_STD_Q4

1.68 (1.59–1.77)

 < .0001

1.72 (1.60–1.85)

 < .0001

1.63 (1.51–1.76)

 < .0001

MI

vikt_STD_Q2

0.99 (0.90–1.08)

0.7542

1.03 (0.92–1.16)

0.5893

0.91 (0.79–1.06)

0.2412

0.085

vikt_STD_Q3

1.04 (0.65–1.15)

0.3902

1.04 (0.92–1.18)

0.5205

1.04 (0.89–1.22)

0.5924

vikt_STD_Q4

1.12 (1.02–1.24)

0.0225

1.07 (0.94–1.22)

0.3382

1.23 (1.05–1.44)

0.0109

Stroke

vikt_STD_Q2

1.04 (0.95–1.14)

0.3497

1.11 (0.98–1.25)

0.0879

0.97 (0.85–1.11)

0.6472

0.366

vikt_STD_Q3

1.07 (0.98–1.18)

0.1344

1.09 (0.96–1.23)

0.2022

1.06 (0.93–1.22)

0.3750

vikt_STD_Q4

1.24 (1.13–1.37)

 < .0001

1.28 (1.12–1.47)

0.0002

1.20 (1.04–1.38)

0.0151

PCI

vikt_STD_Q2

0.97 (0.87–1.07)

0.5287

0.98 (0.87–1.11)

0.7819

0.92 (0.76–1.12)

0.4182

0.447

vikt_STD_Q3

0.97 (0.87–1.08)

0.5657

0.94 (0.81–1.07)

0.3136

1.04 (0.86–1.27)

0.6750

vikt_STD_Q4

1.00 (0.89–1.12)

0.9597

0.94 (0.81–1.08)

0.3517

1.16 (0.95–1.42)

0.1394

CABG

vikt_STD_Q2

0.86 (0.72–1.02)

0.0858

0.84 (0.69–1.03)

0.0939

0.92 (0.64–1.33)

0.6639

0.701

vikt_STD_Q3

0.84 (0.70–1.01)

0.0707

0.84 (0.68–1.03)

0.0892

0.86 (0.58–1.29)

0.4640

vikt_STD_Q4

0.90 (0.74–1.09)

0.2915

0.88 (0.71–1.10)

0.2711

0.95 (0.63–1.44)

0.8197

HF

vikt_STD_Q2

1.03 (0.95–1.11)

0.4831

1.07 (0.96–1.19)

0.2308

0.99 (0.89–1.10)

0.8338

0.828

vikt_STD_Q3

1.18 (1.09–1.27)

 < .0001

1.26 (1.13–1.39)

 < .0001

1.09 (0.98–1.22)

0.1262

vikt_STD_Q4

1.43 (1.32–1.55)

 < .0001

1.48 (1.32–1.65)

 < .0001

1.39 (1.24–1.55)

 < .0001

PAD

vikt_STD_Q2

1.00 (0.86–1.17)

0.9761

1.03 (0.85–1.26)

0.7363

0.95 (0.75–1.21)

0.6702

0.598

vikt_STD_Q3

1.15 (0.98–1.34)

0.0833

1.10 (0.90–1.35)

0.3560

1.20 (0.94–1.53)

0.1342

vikt_STD_Q4

1.55 (1.33–1.81)

 < .0001

1.43 (1.17–1.75)

0.0006

1.69 (1.34–2.14)

 < .0001

Lower limb revascularization

vikt_STD_Q2

0.92 (0.78–1.09)

0.3244

0.96 (0.77–1.20)

0.7338

0.87 (0.68–1.12)

0.2895

0.801

vikt_STD_Q3

1.07 (0.90–1.26)

0.4522

1.13 (0.90–1.41)

0.3087

1.00 (0.77–1.29)

0.9779

vikt_STD_Q4

1.31 (1.10–1.56)

0.0022

1.32 (1.04–1.67)

0.0230

1.30 (1.01–1.67)

0.0447

Foot Ulcer

vikt_STD_Q2

1.02 (0.82–1.27)

0.8462

1.01 (0.75–1.37)

0.9373

1.01 (0.73–1.40)

0.9364

0.239

vikt_STD_Q3

1.30 (1.04–1.61)

0.0194

1.25 (0.93–1.69)

0.1380

1.31 (0.95–1.79)

0.0989

vikt_STD_Q4

1.61 (129–2.00)

 < .0001

1.45 (1.07–1.97)

0.0171

1.73 (1.27–2.36)

0.0006