Characteristic | Quartiles of body weight variability | p-value | |||
---|---|---|---|---|---|
I | II | III | IV | ||
No. of patients | 24,602 | 25,315 | 25,453 | 25,206 | |
Mean interval between BW measurements in years (std) | 0.5 (0.08) | 0.6 (0.09) | 0.6 (0.08) | 0.5 (0.07) | NS |
Weight SD | 0.9 (0.6–1.1) | 1.7 (1.5–1.9) | 2.6 (2.3–2.9) | 4.5 (3.8–6.1) | < 0.0001 |
Gender (% males) | 52.9 | 56.1 | 57.5 | 56,0 | < 0.0001 |
Age (years) | 66.0 (58.0–73.0) | 65.0 (57.0–72.0) | 64.0 (55.0–71.0) | 62.0 (53.0–69.0) | < 0.0001 |
Smoking | 14.0 | 14.6 | 15.9 | 18.2 | < 0.0001 |
BMI | 28.1 (25.3–31.4) | 29.0 (26.1–32.4) | 29.6 (26.6–33.5) | 30.7 (27.0–35.1) | < 0.0001 |
Body weight | 81.3 (71.6–92.0) | 85.0 (74.5–96.0) | 88.0 (77.0–100.0) | 91.1 (78.8–106.0) | < 0.0001 |
Duration of diabetes | < 0.0001 | ||||
≤ 2 years | 14.8 | 15.4 | 16.9 | 18.8 | |
2.1–5 years | 48.2 | 53.7 | 57.5 | 58.5 | |
5.1–10 years | 18.5 | 15.8 | 13.5 | 12.0 | |
> 10 years | 18.5 | 15.1 | 12.1 | 10.6 | |
HbA1c (mmol/mol) | 51.0 (45.0–58.0) | 50.0 (45.0–58.0) | 49.0 (44.0–57.0) | 47.0 (42.0–56.0) | < 0.0001 |
Systolic blood pressure (mmHg) | 135 (125–144) | 135 (125–142) | 134 (125–140) | 132 (124–140) | < 0.0001 |
Diastolic blood pressure (mmHg) | 80 (70–82) | 80 (70–84) | 80 (70–84) | 80 (71–85) | < 0.0001 |
Total cholesterol (mmol/l) | 4.7 (4.1–5.4) | 4.6 (4.0–5.4) | 4.6 (4.0–5.4) | 4.6 (4.0–5.4) | < 0.0001 |
HDL cholesterol (mmol/l) | 1.2 (1.0–1.5) | 1.2 (1.0–1.5) | 1.2 (1.0–1.5) | 1.2 (1.0–1.5) | < 0.0001 |
LDL cholesterol (mmol/l) | 2.6 (2.1–3.3) | 2.6 (2.0–3.3) | 2.6 (2.0–3.2) | 2.6 (2.0–3.3) | < 0.0001 |
Triglycerides (mmol/l) | 1.5 (1.1–2.1) | 1.6 (1.1–2.2) | 1.6 (1.1–2.2) | 1.5 (1.1–2.2) | < 0.0001 |
Albuminuria | < 0.0001 | ||||
No albuminuria | 75.9 | 77.2 | 77.2 | 76.4 | |
Microalbuminuria | 13.5 | 14.0 | 14.2 | 14.3 | |
Macroalbuminuria | 3.4 | 3.3 | 3.4 | 4.0 | |
Not available | 7.2 | 5.5 | 5.4 | 4.0 | |
eGFR (ml/min/1.73m2) | 82.7 (69.2–97.8) | 83.5 (70.0–98.3) | 84.8 (70.8–99.8) | 86.4 (72.1–101.6) | < 0.0001 |
Diabetes retinopathy | 16.4% | 16.7% | 15.7% | 16.1% | < 0.0001 |
Diabetes treatment | < 0.0001 | ||||
Lifestyle only | 15.9 | 15.0 | 14.5 | 18.0 | |
Oral agents | 64.3 | 65.6 | 65.9 | 60.8 | |
Insulin | 7.3 | 6.8 | 7.5 | 8.6 | |
Insulin + oral agents | 12.5 | 12.6 | 12.1 | 12.6 | |
Antihypertensive medication | 70.1 | 69.9 | 70.0 | 68.3 | < 0.0001 |
Statin medication | 59.0 | 59.6 | 59.0 | 54.7 | < 0.0001 |
Aspirin | 23.3 | 22.3 | 20.3 | 17.5 | < 0.0001 |