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Table. 1 Proteomics pairwise analysis of digested pellet deposits from acute COVID-19 and Long COVID/PASC vs fully digested samples from controls and Type 2 Diabetes

From: Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin

Digested pellet deposits (microclots) from acute COVID-19 samples vs digested plasma from Control samples
These proteins are present in both sample types; and a fold change value more than 1 = the protein that more prevalent inside the digested pellet deposits from COVID-19 samples. These proteins were concentrated inside the digested pellet deposits
Protein name Fold change p-value
von Willebrand Factor 4.5 0.02
Complement component C4b 4.2 0.05
C-reactive protein 18.7 0.003
Digested pellet deposits from Long COVID/PASC microclots samples vs digested plasma from Control samples
These proteins are present in both sample types; and a fold change value more than 1 = the protein that more prevalent inside the digested pellet deposits from Long COVID/PASC samples. These proteins were concentrated inside the digested pellet deposits
Coagulation factor XIII A chain 6.9 0.001
Plasminogen 3 0.001
Fibrinogen alpha chain 4.1 0.0001
α2 antiplasmin (α2AP) 7.98 0.0002
von Willebrand Factor 10.2 0.001
C-reactive protein 11.2 0.007
Serum Amyloid A (SAA4) 17.5 0.01
Complement component C7 20 0.0002
Digested pellet deposits from Long COVID/PASC microclots samples vs digested pellet deposits (microclots) from acute COVID-19 samples
These proteins are present in both sample types; and a fold change value more than 1 = the protein that more prevalent inside the digested pellet deposits from Long COVID/PASC samples. These proteins were concentrated inside the digested pellet deposits
Plasminogen 2.3 0.0007
Fibrinogen β chain 2.8 0.0007
Coagulation factor XIII B 2.7 0.01
Fibrinogen α chain 3.1 0.0002-
Complement component C6 7.5 0.01
α2 antiplasmin (α2AP) 9.2 0.0003
Complement factor 1 25 0.0009
Digested plasma from T2DM samples (after 1st trypsinization step) vs Long COVID/PASC digested pellet deposits (microclots) (after 2nd trypsinization step)
These proteins are present in both sample types; and a fold change value more than 1 = the protein that more prevalent inside the digested plasma from the Long COVID samples
CytoskeletalKeratin, type I 24.7 0.01
Cytoskeletal Keratin, type II 14 0.02
C1q subcomponent subunit B 1 0.03
Digested plasma from control plasma samples vs digested plasma samples from T2DM samples (both plasma sample analysed after 1st trypsinization step)
These proteins are present in both sample types; and a fold change value more than 1 = the protein that more prevalent inside the digested plasma from the diabetes samples
Complement C1r subcomponent-like protein 1.5 0.04
SAA1 2.5 0.03
  1. All sample types underwent a two-step trypsinization process. Controls vs acute COVID-19; Controls vs Long COVID/PASC; acute COVID-19 vs Long COVID/PASC. The proteins showed here are in both sample types; and value more than 1 = the protein more prevalent in a specific digested pellet deposit. We also compared fold changes between digested plasma (after 1st trypsinisation step) of samples from controls and Type 2 Diabetes Mellitus (T2DM) and between samples from T2DM and Long COVID/PASC (supernatant after 1st trypsinization step only)