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Table 4 Association of principal components factors with time to all-cause mortality or all-cause hospitalization

From: Circulating long chain acylcarnitines and outcomes in diabetic heart failure: an HF-ACTION clinical trial substudy

Factor Overall Non-diabetic Diabetic Interaction p value
HR p value BH p value HR p value BH p value HR p value BH p value
Unadjusted
 1 0.964 0.325 0.407        
 2 1.020 0.602 0.602        
 3 1.094 0.047 0.094        
 4 1.162 0.006 0.024 1.265 0.008 0.008 1.097 0.186 0.279 0.244
 5 0.800 5E-11 6E-10 0.864 0.004 0.006 0.629 8E-11 2E-10 2E-4
 6 1.115 0.021 0.050        
 7 0.896 0.018 0.050        
 8 0.884 0.004 0.024 0.783 0.001 0.003 0.943 0.283 0.283 0.039
 9 1.086 0.078 0.134        
 10 1.042 0.373 0.407        
 11 1.059 0.262 0.393        
 12 1.041 0.365 0.407        
Adjusteda
 4 0.933 0.352 0.352 0.865 0.289 0.289 0.975 0.783 0.832 0.725
 5 0.798 2.74E-8 8.22E-8 0.902 0.104 0.156 0.635 3.21E-9 9.62E-9 0.001
 8 0.939 0.213 0.320 0.814 0.028 0.084 1.01 0.832 0.832 0.012
  1. aModel is adjusted for race (white vs. non-white), sex, age, baseline left ventricular ejection fraction, creatinine, BMI, baseline peak VO2, treatment group, BUN and CPX duration
  2. P-values in bold indicate statistically significant association