Table 2 Principal components factors and their association with diabetic status
Factor | Loading | Description | Metabolites with absolute loading > 0.4 | Diabetes beta | p value | BH p value |
|---|---|---|---|---|---|---|
1 | (−) | Medium and long chain acylcarnitines | C8, C10:1, C10, C12:1, C12, C14:2, C14:1, C14, C16, C18:2, C18:1, C18, C16:2, C16:1 | 0.138 | 0.076 | 0.102 |
2 | (+) | Long chain dicarboxylacylcarnitines | C10-OH/C8-DC, C12-OH/C10-DC, C14:1-OH/C12:1-DC, C14-OH/C12-DC, C16-OH/C14-DC, C18:1-OH/C16:1-DC, C18-OH/C16-DC, C20, C18:1-DC, C20-OH/C18-DC, C22 | 0.454 | 4E-9 | 2E-8 |
3 | (+) | Short chain acylcarnitines | C2, C3, C4/Ci4, C5's, C5-OH/C3-DC | 0.214 | 0.006 | 0.017 |
4 | (+) | Medium chain dicarboxylacylcarnitines | Cit, C5-OH/C3-DC, Ci4-DC/C4-DC, C5-DC, C6-DC, C10-OH/C8-DC, C6:1-DC/C8:1-OH, C8:1-DC | 0.138 | 0.022 | 0.053 |
5 | Mixed | Long chain acylcarnitines | Arg (+), C16(−), C18:2(−), C18:1(−), C18(−), C20:4(−) | − 0.012 | 0.875 | 0.875 |
6 | (−) | Amino acids | Gly, Ser, Arg | 0.429 | 3E-8 | 1E-7 |
7 | (+) | Miscellaneous | Met, C5:1, C22, C16:1-OH/C14:1-DC | 1.067 | 1E-49 | 1E-48 |
8 | (−) | Medium chain acylcarnitines | C8:1, C10:3, C10:2, C10:1, C6:1-DC/C8:1-OH, C8:1-DC | − 0.128 | 0.097 | 0.116 |
9 | (−) | Amino acids | Ala, Pro, His | − 0.141 | 0.069 | 0.102 |
10 | Mixed | Amino acids | His(+), Asx(−), Arg(+) | − 0.092 | 0.234 | 0.255 |
11 | (+) | Long chain dicarboxylacylcarnitines | C2, C4-OH, C14:1-OH/C12:1-DC | 0.167 | 0.031 | 0.062 |
12 | (+) | Branched chain amino acids|amino acids | Val, Leu/Ile, Phe, Tyr, Orn | − 0.147 | 0.057 | 0.098 |