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Table 2 Principal components factors and their association with diabetic status

From: Circulating long chain acylcarnitines and outcomes in diabetic heart failure: an HF-ACTION clinical trial substudy

Factor Loading Description Metabolites with absolute loading  >  0.4 Diabetes beta p value BH p value
1 (−) Medium and long chain acylcarnitines C8, C10:1, C10, C12:1, C12, C14:2, C14:1, C14, C16, C18:2, C18:1, C18, C16:2, C16:1 0.138 0.076 0.102
2 (+) Long chain dicarboxylacylcarnitines C10-OH/C8-DC, C12-OH/C10-DC, C14:1-OH/C12:1-DC, C14-OH/C12-DC, C16-OH/C14-DC, C18:1-OH/C16:1-DC, C18-OH/C16-DC, C20, C18:1-DC, C20-OH/C18-DC, C22 0.454 4E-9 2E-8
3 (+) Short chain acylcarnitines C2, C3, C4/Ci4, C5's, C5-OH/C3-DC 0.214 0.006 0.017
4 (+) Medium chain dicarboxylacylcarnitines Cit, C5-OH/C3-DC, Ci4-DC/C4-DC, C5-DC, C6-DC, C10-OH/C8-DC, C6:1-DC/C8:1-OH, C8:1-DC 0.138 0.022 0.053
5 Mixed Long chain acylcarnitines Arg (+), C16(−), C18:2(−), C18:1(−), C18(−), C20:4(−) − 0.012 0.875 0.875
6 (−) Amino acids Gly, Ser, Arg 0.429 3E-8 1E-7
7 (+) Miscellaneous Met, C5:1, C22, C16:1-OH/C14:1-DC 1.067 1E-49 1E-48
8 (−) Medium chain acylcarnitines C8:1, C10:3, C10:2, C10:1, C6:1-DC/C8:1-OH, C8:1-DC − 0.128 0.097 0.116
9 (−) Amino acids Ala, Pro, His − 0.141 0.069 0.102
10 Mixed Amino acids His(+), Asx(−), Arg(+) − 0.092 0.234 0.255
11 (+) Long chain dicarboxylacylcarnitines C2, C4-OH, C14:1-OH/C12:1-DC 0.167 0.031 0.062
12 (+) Branched chain amino acids|amino acids Val, Leu/Ile, Phe, Tyr, Orn − 0.147 0.057 0.098
  1. P-values in bold indicate a statistically significant association