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Table 1 Baseline patient characteristics

From: Circulating long chain acylcarnitines and outcomes in diabetic heart failure: an HF-ACTION clinical trial substudy

Variable Overall (n  =  664) Non-diabetic (n = 305) Diabetic (n = 359) p-value
Clinical variables
 Age (years), [median(IQR)] 60.0 [52.6, 68.1] 58.5 [50.1, 68.2] 61.1 [54.6, 68.1] 0.010
 Female sex (%) 183 (27.6) 93 (30.5) 90 (25.1) 0.141
 Race (%)
  American Indian 5 (0.8) 0 (0.0) 5 (1.4) 0.030
  Asian 9 (1.4) 1 (0.3) 8 (2.2)
  African American 213 (32.1) 97 (31.8) 116 (32.3)
  White 410 (61.7) 195 (63.9) 215 (59.9)
  Multiracial 15 (2.3) 9 (3.0) 6 (1.7)
  Unknown 12 (1.8) 3 (1.0) 9 (2.5)
 BMI [median (IQR)] 30.7 [26.8, 36.1] 29.8 [25.6, 34.4] 32.0 [27.8, 37.3] < 0.001
 Pulse pressure (mmHg), [median (IQR)] 42.0 [36.0, 54.0] 40.0 [34.0, 50.0] 46.0 [37.2, 56.0] < 0.001
 History of atrial arrhythmia (%) 142 (21.4) 62 (20.3) 80 (22.3) 0.605
 Currently smoking (%) 95 (14.4) 59 (19.5) 36 (10.1) 0.001
 LVEF (%) [median (IQR)] 25.0 [20.0, 30.0] 25.0 [19.6, 30.1] 25.0 [20.0, 29.9] 0.510
 NT-Pro BNP [median (IQR)] 813.0 [342.5, 1859.0] 751.9 [320.8, 1854.0] 899.1 [377.5, 1855.2] 0.252
 Hemoglobin (g/dL) [median (IQR)] 13.3 [12.1, 14.4] 13.3 [12.3, 14.5] 13.1 [12.0, 14.3] 0.076
 Creatinine (mg/dL) (median [IQR]) 1.2 [1.0, 1.5] 1.1 [1.0, 1.4] 1.3 [1.0, 1.6] < 0.001
 Hemoglobin A1C [median (IQR)] 6.9 [6.2, 8.0] 5.9 [5.5, 6.3] 7.2 [6.4, 8.4] < 0.001
 BUN (mg/dL) [median (IQR)] 21.0 [15.0, 29.0] 18.0 [14.0, 24.0] 24.0 [17.0, 33.0] < 0.001
 ACEi dose (mg) [median (IQR)] 20.0 [0.0, 40.0] 20.0 [0.0, 40.0] 20.0 [0.0, 40.0] 0.610
 Beta blocker dose (mg) [median (IQR)] 25.0 [13.0, 50.0] 25.0 [13.0, 50.0] 50.0 [16.0, 50.0] 0.008
Exercise variables
 Baseline peak VO2 (mg/kg/min) [median (IQR)] 14.0 [11.2, 16.9] 14.8 [11.9, 17.7] 13.4 [10.4, 16.6] < 0.001
 6-minute walk distance (m) [median (IQR]] 361.0 [289.7, 426.3] 365.8 [305.4, 435.1] 353.0 [274.7, 415.6] 0.012
  1. BMI body mass index; LVEF left ventricular ejection fraction; BNP brain natriuretic peptide; BUN blood urea nitrogen; ACEi angiotensin converting enzyme inhibitor; VO2, oxygen consumption
  2. Bold values indicate a statistically significance difference in P-values