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Table 3 Summary of metabolites discriminating MetS

From: A molecular signature for the metabolic syndrome by urine metabolomics

Metabolite* Variable importance in the model log2FC P-value Associated RF
Glucose 1056.86 1.66 (1.37, 1.94) 5.88e−97 RF1, this study and definition
Formic acid 436.74 − 0.79 (− 0.87, − 0.71) 3.53e−77 n. a
Steroid lipids 364.47 0.57 (0.3, 0.86) 3.68e−31 RF3, this study and definition
TMAO§/1-Methyluric acid 218.32 − 0.54 (− 0.7, − 0.38) 1.58e−30 RF2 [47]
Trigonelline 201.66 − 0.4 (− 0.5, − 0.3) 1.38e−06 RF2 [48]
Tryptophan 198.95 − 0.38 (-0.44, − 0.31) 1.38e−38 RF2 [48]
Quinolinic acid 192.41 0.41 (0.24, 0.59) 1.99e−17 RF2 [36]
Imidazole 184.05 − 0.57 (− 0.7, − 0.43) 1.20e−26 RF4 [29]
Histidine 181.71 − 0.56 (− 0.75, − 0.37) 8.42e−16 RF4 [29]
4-HPPA§/p-cresol sulfate 171.38 0.53 (0.4, 0.67) 1.56e−19 RF1 [43]
Salicyluric acid 164.22 0.42 (0.29, 0.56) 8.77e−14 RF2 [48]
Maltitol 155.43 0.65 (0.45, 0.85) 2.22e−05 RF1 [28]
Methylhippuric acid 153.23 − 0.45 (− 0.54, − 0.36) 3.79e−21 n.a
Nicotinuric acid 146.41 − 0.38 (− 0.5, − 0.27) 1.18e−09 RF2 [48]
  1. n.a: not applicable
  2. *For metabolites with more than one associated bin, those results with the higher abs(log2FC) are showed
  3. Binary logarithms of fold-changes (log2FC), their 95% confidence intervals and p-values were calculated between MetS and non-MetS conditions
  4. Numbers in parentheses represent the bibliographic reference where this metabolite is related to the pertaining RF
  5. §4-HPPA: 4-hydroxyphenylpyruvic acid; TMAO: trimethylamine N-oxide