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Table 1 Definition criteria for the diagnosis of MetS according to the different organizations

From: A molecular signature for the metabolic syndrome by urine metabolomics

  WHO EGIR AACE NCEP:ATPIII IDF Harmonized
Glucose metabolism (FG MG/DL) IGT, IFG, T2DM or lowered insulin sensitivity IR
FG ≥ 110
IGT or IFG (but not diabetes) FG ≥ 100 FG ≥ 100 or
T2DM
FG ≥ 100 or treatment
Obesity (BMI KG/M2, WC CM) WHR(m) > 0.90 WHR(f) ˃ 0.85 or BMI ˃ 30 WC(m) ≥ 94 WC(f) ≥ 80 BMI ˃ 25 WC(m) ≥ 102 WC(f) ≥ 88 Elevated WC, ethnicity, and gender specific Elevated WC, population, and country specific
Dyslipidemia (TG, HDL-C MG/DL) TG ˃ 150 or HDL-C(m) ˂ 35 HDL-C(f) ˂ 39 TG ˃ 177 or HDL-C ˂ 39 TG ≥ 150 or HDL-C(m) ˂ 40, HDL-C(f) ˂ 50 TG ≥ 150 or HDL-C(m) ˂ 40, HDL-C(f) ˂ 50 TG ≥ 150 or treatment or HDL-C(m) ˂ 40, HDL-C(f) ˂ 50 or treatment TG ≥ 150 or treatment or HDL-C(m) ˂ 40, HDL-C(f) ˂ 50 or treatment
Hypertension (BP MMHG)  ≥ 140/90  ≥ 140/90  ≥ 130/85  ≥ 130/85  ≥ 130/85 or treatment  ≥ 130/85 or treatment
Other factors Microalbominuria ˃ 30 mg/g Not relevant Other risk factors§ Not relevant Not relevant Not relevant
  1. Organizations: WHO: World Health Organization; EGIR: European Group for the Study of Insulin; AACE: American Association of Clinical Endocrinology; NCEP:ATPIII: National Cholesterol Education Program-Third Adult Treatment Panel; IDF: International Diabetes Federation
  2. IFG: impaired fasting glucose; IGT: impaired glucose tolerance; FG: fasting plasma glucose; T2DM: type 2 diabetes; WC: waist circumference; WHR: waist-hip ratio; BMI: body mass index; TG: triglycerides; HDL-C: HDL cholesterol; BP: blood pressure; m: male; f: female
  3. Bold highlighted factors are compulsory for the given definition. Obtained from refs. [6, 27, 46]
  4. IR: Insulin resistance, defined as hyperinsulinemia: top 25% of fasting insulin values among the nondiabetics
  5. §Family history of T2DM, sedentary lifestyle, advanced age, ethnic groups susceptible to T2DM, polycystic ovary syndrome