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Table 1 Definition criteria for the diagnosis of MetS according to the different organizations

From: A molecular signature for the metabolic syndrome by urine metabolomics

 

WHO

EGIR

AACE

NCEP:ATPIII

IDF

Harmonized

Glucose metabolism (FG MG/DL)

IGT, IFG, T2DM or lowered insulin sensitivity

IR

FG ≥ 110

IGT or IFG (but not diabetes)

FG ≥ 100

FG ≥ 100 or

T2DM

FG ≥ 100 or treatment

Obesity (BMI KG/M2, WC CM)

WHR(m) > 0.90 WHR(f) ˃ 0.85 or BMI ˃ 30

WC(m) ≥ 94 WC(f) ≥ 80

BMI ˃ 25

WC(m) ≥ 102 WC(f) ≥ 88

Elevated WC, ethnicity, and gender specific

Elevated WC, population, and country specific

Dyslipidemia (TG, HDL-C MG/DL)

TG ˃ 150 or HDL-C(m) ˂ 35 HDL-C(f) ˂ 39

TG ˃ 177 or HDL-C ˂ 39

TG ≥ 150 or HDL-C(m) ˂ 40, HDL-C(f) ˂ 50

TG ≥ 150 or HDL-C(m) ˂ 40, HDL-C(f) ˂ 50

TG ≥ 150 or treatment or HDL-C(m) ˂ 40, HDL-C(f) ˂ 50 or treatment

TG ≥ 150 or treatment or HDL-C(m) ˂ 40, HDL-C(f) ˂ 50 or treatment

Hypertension (BP MMHG)

 ≥ 140/90

 ≥ 140/90

 ≥ 130/85

 ≥ 130/85

 ≥ 130/85 or treatment

 ≥ 130/85 or treatment

Other factors

Microalbominuria ˃ 30 mg/g

Not relevant

Other risk factors§

Not relevant

Not relevant

Not relevant

  1. Organizations: WHO: World Health Organization; EGIR: European Group for the Study of Insulin; AACE: American Association of Clinical Endocrinology; NCEP:ATPIII: National Cholesterol Education Program-Third Adult Treatment Panel; IDF: International Diabetes Federation
  2. IFG: impaired fasting glucose; IGT: impaired glucose tolerance; FG: fasting plasma glucose; T2DM: type 2 diabetes; WC: waist circumference; WHR: waist-hip ratio; BMI: body mass index; TG: triglycerides; HDL-C: HDL cholesterol; BP: blood pressure; m: male; f: female
  3. Bold highlighted factors are compulsory for the given definition. Obtained from refs. [6, 27, 46]
  4. IR: Insulin resistance, defined as hyperinsulinemia: top 25% of fasting insulin values among the nondiabetics
  5. §Family history of T2DM, sedentary lifestyle, advanced age, ethnic groups susceptible to T2DM, polycystic ovary syndrome