Fig. 1

Univariate and Multivariate analyses for the MetS subtypes. A PCA for the mean profiles for the 16 conditions under consideration. Each condition contains (or not) the risk factor according to Table 1. Color ellipses indicates clusters for subjects with: diabetes (green), hypertension (purple), both factors (yellow) or none of the two (blue). B Heatmap for the different conditions as compared to the apparently healthy condition (0000). The conditions (in the abscise axis) and the bins/metabolites (in the ordinate axis) have been sorted according to cluster analysis. The relevant bins that contributed to the heatmap have been assigned to the corresponding metabolite, as indicated. The fold change is colour-coded according to the bar legend. For each condition, the statistical significance of the variation with respect to apparently healthy individuals is determined by the p-value, shown inside the squares. C Spearman correlation distances to the healthy condition for all the conditions. Colours represent the distance to the apparently healthy (0000) condition, as indicated in the legend. The lines connect adjacent conditions. MetS definition according to WHO, EGIR and AACE is represented by squares and triangles; definition from NCEP:ATPIII and Harmonized is represented by squares, triangles and rhombus; definition by IDF is represented by squares and rhombus. 4-HPPA: 4-hydroxyphenylpyruvic acid; TMAO: trimethylamine N-oxide. The orange ellipse embraces all the conditions that would correspond to MetS according to our metabolic definition