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Table 3 Uni- and multivariable linear regression analyses between lipids, TRL and LDL particle concentrations, subfractions and sizes with HOMA‐β

From: Triglyceride-rich lipoprotein and LDL particle subfractions and their association with incident type 2 diabetes: the PREVEND study

 

Total population (n = 5124, std β, P-values

P-value for interaction

T2D at baseline ((n = 308), std β, P-values

No T2D at baseline (n = 4818), std β, P-values

Variables

Univariate

Univariate

Model 1a

Univariate

Model 1b

Total cholesterol

0.028*

0.014

− 0.081

− 0.027

0.034*

0.001

Non-HDL cholesterol

0.067***

0.011

− 0.046

− 0.014

0.086***

0.021

LDL-C

0.044**

0.067

− 0.041

− 0.038

0.050*

0.009

HDL-C

− 0.118***

0.201

− 0.150**

− 0.055

− 0.156***

− 0.058***

Triglycerides

0.134***

0.011

0.030

− 0.084

0.183***

0.057***

ApoB

0.072***

0.010

− 0.042

− 0.011

0.093***

0.025

TRLP

0.065***

0.077

− 0.018

− 0.030

0.091***

0.027

Very large TRLP

0.026

0.003

− 0.069

− 0.197**

0.063***

− 0.038*

Large TRLP

0.132***

0.020

0.014

− 0.136*

0.180***

0.049**

Medium TRLP

0.105***

0.054

0.012

0.016

0.135***

0.067***

Small TRLP

− 0.003

0.977

− 0.004

0.028

− 0.007

0.007

Very small TRLP

0.011

0.899

0.005

− 0.005

0.012

0.015

TRL size

0.106***

0.116

0.047

− 0.082

0.149***

0.033*

LDLP

0.069***

0.025

− 0.030

− 0.020

0.088***

0.023

Large LDLP

− 0.070***

0.130

− 0.052

0.005

− 0.112***

− 0.030*

Medium LDLP

0.001

0.343

0.027

0.079

− 0.018

0.012

Small LDLP

0.045**

0.475

0.005

− 0.106

0.070***

0.022

LDL size

− 0.068***

0.031

− 0.003

0.121*

− 0.116***

− 0.036*

  1. Standardized regression coefficients are shown (Stdß) are shown. Loge transformed values are used for variables with a skewed distribution
  2. Model 1a: sex, age, and HOMA‐β, BMI, lipid-lowering medication, anti-hypertensive medication, and glucose-lowering medication
  3. Model 1b: sex, age, and HOMA‐β, BMI, lipid-lowering medication, anti-hypertensive medication
  4. HOMA-IR Homeostatic model assessment of insulin resistance, HOMA‐β Homeostatic model assessment of β-cell function, BMI Body mass index, LDL-C Low-density lipoprotein cholesterol, ApoB apolipoprotein B, LDLP low density lipoprotein particles, TRLP triglyceride rich lipoprotein particles
  5. *P < 0.05; **P < 0.01; ***P < 0.001. P-value for interaction indicates difference between each variable and status of T2D at baseline in unadjusted analysis. Bold values indicate statistically significant.