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Table 7 Association between inpatient statin intensity and severe disease outcomes- Mortality, Mechanical ventilation and ICU admission

From: Statins and clinical outcomes in hospitalized COVID-19 patients with and without Diabetes Mellitus: a retrospective cohort study with propensity score matching

Characteristic Mortality ICU Admission Mechanical ventilation
  OR (95% CI) p-value OR (95% CI) p-value OR (95% CI) p-value
Total cohort*
 No statin Ref   Ref   Ref  
 Low 0.35 (0.11–1.07) 0.07 0.58 (0.21–1.63) 0.3 0.71 (0.24–2.09) 0.53
 Moderate 0.61 (0.35–1.06) 0.08 0.65 (0.39–1.09) 0.11 0.49 (0.27–0.90) 0.02
 High 0.70 (0.44–1.13) 0.14 0.62 (0.40–0.96) 0.03 0.59 (0.36–0.95) 0.03
PSM- Total cohort
 No statin Ref   Ref   Ref  
 Low 0.31 90.09–1.13) 0.08 0.29 (0.08–1.04) 0.06 0.45 (0.12–1.61) 0.22
 Moderate 0.40 (0.23–0.72) 0.002 0.54 (0.31–0.92) 0.02 0.43 (0.23–0.80) 0.007
 High 0.54 (0.34–0.86) 0.009 0.59 (0.38–0.93) 0.02 0.58 (0.36–0.95) 0.03
Diabetes Mellitus patients
 No statin Ref   Ref   Ref  
 Low 0.14 (0.03–0.76) 0.02 0.28 (0.07–1.19) 0.09 0.35 (0.08–1.51) 0.16
 Moderate 0.47 (0.22–0.98) 0.04 0.51 (0.25–1.03) 0.06 0.53 (0.26–1.09) 0.09
 High 0.36 (0.18–0.70) 0.003 0.71 (0.40–1.29) 0.26 0.35 (0.18–0.69) 0.003
PSM- Diabetes Mellitus
 No statin Ref   Ref   Ref  
 Low 0.26 (0.06–1.27) 0.1 0.41 (0.10–1.60) 0.2 0.31 (0.06–1.49) 0.14
 Moderate 0.45 (0.22–0.94) 0.03 0.51 (0.25–1.02) 0.06 0.53 (0.26–1.10) 0.09
 High 0.37 (0.20–0.71) 0.003 0.66 (0.37–1.20) 0.17 0.40 (0.21–0.78) 0.007
  1. *Adjusted for age, sex, race, BMI, insurance, days to presentation, CURB-65 and comorbidities which include preexisting lung diseases, smoking, hypertension, coronary artery disease, diabetes mellitus, chronic kidney disease, ESRD on dialysis, congestive heart failure, any cancer, chronic liver disease, hyperlipidemia and history of previous stroke
  2. Adjusted for age, sex, race, BMI, insurance, days to presentation, CURB-65 and comorbidities which include preexisting lung diseases, smoking, hypertension, coronary artery disease, chronic kidney disease, ESRD on dialysis, congestive heart failure, any cancer, chronic liver disease, hyperlipidemia and history of previous stroke