Skip to main content

Table 3 Association between inpatient statins and severe disease outcomes- Mortality, Mechanical ventilation and ICU admission

From: Statins and clinical outcomes in hospitalized COVID-19 patients with and without Diabetes Mellitus: a retrospective cohort study with propensity score matching

Characteristic Mortality ICU Admission Mechanical ventilation
OR (95% CI) p-value OR (95% CI) p-value OR (95% CI) p-value
Total cohort
 Unadjusted 0.76 (0.55–1.05) 0.1 0.70 (0.51–0.95) 0.02 0.64 (0.45–0.90) 0.01
 Fully adjusted* 0.61 (0.42–0.90) 0.01 0.61 (0.43–0.87) 0.006 0.54 (0.36–0.80) 0.002
 Optimal Model 0.64 (0.45–0.91) 0.01 0.64 (0.46–0.89) 0.008 0.56 (0.39–0.82)§ 0.002
 PS matched cohort 0.47 (0.32–0.70)  < 0.001 0.55 (0.37–0.80) 0.002 0.51 (0.34–0.78) 0.002
 PS matched cohort, double robust approach# 0.44 (0.30–0.66)  < 0.001 0.54 (0.37–0.80) 0.002 0.51 (0.33–0.77) 0.001
Diabetes mellitus patients
 Unadjusted 0.45 (0.29–0.71)  < 0.001 0.58 (0.38–0.89) 0.01 0.44 (0.28–0.70)  < 0.001
 Fully adjusted** 0.35 (0.21–0.61)  < 0.001 0.56 (0.34–0.90) 0.02 0.39 (0.23–0.65)  < 0.001
 Optimal Model 0.37 (0.23–0.62)††  < 0.001 0.58 (0.37–0.90)‡‡ 0.02 0.44 (0.27–0.72)§§  < 0.001
 PS matched- Diabetes 0.39 (0.23–0.66)  < 0.001 0.58 (0.35–0.96) 0.03 0.44 (0.26–0.75) 0.003
Non-diabetes mellitus patients
 Unadjusted 1.21 (0.77–1.91) 0.42 0.72 (0.45–1.15) 0.17 0.81 (0.47–1.39) 0.45
 Fully adjusted** 1.21 (0.67–2.17) 0.52 0.71 (0.41–1.25) 0.23 0.92 (0.49–1.74) 0.79
 PS matched- non-Diabetes 0.95 (0.52–1.75) 0.88 0.61 (0.33–1.14) 0.12 0.82 (0.40–1.68) 0.58
Cohort of patients with history of antecedent statin use
 Unadjusted 0.56 (0.37–0.85) 0.006 0.48 (0.33–0.72)  < 0.001 0.44 (0.29–0.68)  < 0.001
 Fully adjusted* 0.46 (0.28–0.74) 0.002 0.46 (0.30–0.72)  < 0.001 0.40 (0.25–0.65)  < 0.001
  1. *Adjusted for age, sex, race, BMI, insurance, days to presentation, CURB-65 and comorbidities which include preexisting lung diseases, smoking, hypertension, coronary artery disease, Diabetes Mellitus, chronic kidney disease, ESRD on dialysis, congestive heart failure, any cancer, chronic liver disease, hyperlipidemia and history of previous stroke
  2. Variables in the optimal model- age, BMI, CURB-65 and inpatient statin use
  3. Variables in the optimal model- age, CURB-65, Diabetes Mellitus, and inpatient statin use
  4. §Variables in the optimal model- BMI, CURB-65, preexisting lung diseases, Diabetes Mellitus and inpatient statin use
  5. #Adjusted for HTN
  6. **Adjusted for age, sex, race, BMI, insurance, days to presentation, CURB-65 and comorbidities which include preexisting lung diseases, smoking, hypertension, coronary artery disease, chronic kidney disease, ESRD on dialysis, congestive heart failure, any cancer, chronic liver disease, hyperlipidemia and history of previous stroke
  7. ††Variables in the optimal model- age, CURB-65, preexisting lung diseases, congestive heart failure, chronic liver disease, chronic kidney disease and inpatient statin use
  8. ‡‡Variables in the optimal model- BMI, CURB-65 and inpatient statin use
  9. §§Variables in the optimal model- BMI, CURB-65 and inpatient statin use