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Table 1 Baseline characteristics for patients with different FIB levels

From: Prognostic value of fibrinogen in patients with coronary artery disease and prediabetes or diabetes following percutaneous coronary intervention: 5-year findings from a large cohort study

Variables

Total (n = 6140)

FIB-L (n = 2069)

FIB-M (n = 2033)

FIB-H (n = 2038)

P value

Age, years

58.4 ± 10.4

57.3 ± 10.2

58.2 ± 10.2

59.6 ± 10.6

 < 0.001

Male, %

4771 (77.7)

1729(83.6)

1567(77.1)

1475(72.4)

 < 0.001

BMI, kg/m2

25.9 ± 3.2

25.7 ± 3.1

26.1 ± 3.2

25.9 ± 3.3

 < 0.001

Diabetes mellitus, %

1862 (30.3)

521(25.2)

656(32.3)

685(33.6)

 < 0.001

Hypertension, %

3930 (64.0)

1248(60.3)

1328(65.3)

1354(66.4)

 < 0.001

Dyslipidemia, %

4241 (69.1)

1403(67.8)

1436(70.6)

1402(68.8)

0.140

Family history of CAD, %

1433 (23.3)

501(24.2)

479(23.6)

453(22.2)

0.309

Smoking, %

3496 (56.9)

1197(57.9)

1173(57.7)

1126(55.3)

0.169

Prior MI, %

1219 (19.9)

465(22.5)

394(19.4)

360(17.7)

 < 0.001

Prior PCI or CABG, %

1581 (25.7)

621(30.0)

514(25.3)

446(21.9)

 < 0.001

Prior stroke, %

658 (10.7)

204(9.9)

206(10.1)

248(12.2)

0.033

Clinical presentation, %

 < 0.001

 SAP

2572 (41.9)

995 (48.1)

874 (43.0)

703 (34.5)

 

 ACS

3568 (58.1)

1074 (51.9)

1159 (57.0)

1335 (65.5)

 

 LVEF, %

63.0 ± 7.2

63.6 ± 6.8

63.5 ± 6.8

62.0 ± 7.9

 < 0.001

 FBG, mmol/L

6.1 ± 2.0

5.8 ± 1.8

6.1 ± 2.0

6.3 ± 2.2

 < 0.001

 HbA1c, %

6.6 ± 1.2

6.4 ± 1.0

6.6 ± 1.2

6.8 ± 1.4

 < 0.001

 FIB, mg/dL

3.40 ± 0.84

2.62 ± 0.28

3.26 ± 0.17

4.32 ± 0.74

 < 0.001

 hs-CRP, mg/L

3.14 ± 3.77

1.31 ± 1.74

2.34 ± 2.65

5.81 ± 4.64

 < 0.001

 D-dimer, μg/mL

0.41 ± 0.65

0.37 ± 0.70

0.38 ± 0.52

0.48 ± 0.70

 < 0.001

 TC, mmol/L

4.17 ± 1.09

4.00 ± 1.07

4.21 ± 1.08

4.30 ± 1.11

 < 0.001

 HDL-C, mmol/L

1.02 ± 0.28

1.02 ± 0.27

1.03 ± 0.28

1.00 ± 0.28

0.060

 LDL-C, mmol/L

2.48 ± 0.92

2.34 ± 0.91

2.50 ± 0.91

2.59 ± 0.93

 < 0.001

 TG, mmol/L

1.81 ± 1.12

1.75 ± 1.12

1.85 ± 1.13

1.83 ± 1.12

0.015

 Creatinine (μmol/L)

75.4 ± 16.0

74.5 ± 14.1

74.6 ± 15.4

77.0 ± 18.2

 < 0.001

 Lesion vessels

1.4 ± 0.7

1.4 ± 0.6

1.4 ± 0.7

1.5 ± 0.7

 < 0.001

 LM/three-vessel disease, %

2773 (45.2)

865 (41.8)

909 (44.7)

999 (49.0)

 < 0.001

 SYNTAX scorea

12.0 ± 8.2

11.2 ± 7.8

11.9 ± 8.2

12.8 ± 8.5

 < 0.001

 Complete revascularization, %

3310 (53.9)

1201 (58.0)

1090 (53.6)

1019 (50.0)

 < 0.001

 Number of stents

1.8 ± 1.2

1.8 ± 1.1

1.8 ± 1.2

1.9 ± 1.2

0.148

 DES implantation, %

5778 (94.1)

1941 (93.8)

1923 (94.6)

1914 (93.9)

0.520

Medications at discharge, %

 Aspirin

6077 (99.0)

2051(99.1)

2011(98.9)

2015(98.9)

0.680

 Clopidogrel

6020 (98.0)

2023(97.8)

1997(98.2)

2000(98.1)

0.542

 β-blocker

5609 (91.4)

1878(90.8)

1868(91.9)

1863(91.4)

0.443

 ACEI/ARB

3150 (51.3)

983(47.5)

1049(51.6)

1118(54.9)

 < 0.001

 CCB

2875 (46.8)

952(46.0)

973(47.9)

950(46.6)

0.482

 Statin

5923 (96.5)

2002(96.8)

1963(96.6)

1958(96.1)

0.473

 Nitrate

5984 (97.5)

2021(97.7)

1981(97.4)

1982(97.3)

0.683

  1. Values are presented as mean ± standard deviation or number (%)
  2. ACEI angiotensin-converting enzyme inhibitors, ACS acute coronary syndrome, ARB angiotensin II receptor blockers, BMI body mass index, CAD coronary artery disease, CABG coronary artery bypass grafting, CCB calcium channel blocker, DES drug-eluting stent, FIB fibrinogen, FBG fasting blood glucose, hs-CRP high sensitivity C-reactive protein, HbA1c Hemoglobin A1c, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, LM left main disease, LVEF left ventricular ejection fraction, MI myocardial infarction, PCI percutaneous coronary intervention, SAP stable angina pectoris, TC total cholesterol, TG triglycerides
  3. aCalculated using an online calculator (http://www.syntaxscore.com/) by a dedicated research group blinded to the clinical data