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Table 1 Baseline characteristics for patients with different FIB levels

From: Prognostic value of fibrinogen in patients with coronary artery disease and prediabetes or diabetes following percutaneous coronary intervention: 5-year findings from a large cohort study

Variables Total (n = 6140) FIB-L (n = 2069) FIB-M (n = 2033) FIB-H (n = 2038) P value
Age, years 58.4 ± 10.4 57.3 ± 10.2 58.2 ± 10.2 59.6 ± 10.6  < 0.001
Male, % 4771 (77.7) 1729(83.6) 1567(77.1) 1475(72.4)  < 0.001
BMI, kg/m2 25.9 ± 3.2 25.7 ± 3.1 26.1 ± 3.2 25.9 ± 3.3  < 0.001
Diabetes mellitus, % 1862 (30.3) 521(25.2) 656(32.3) 685(33.6)  < 0.001
Hypertension, % 3930 (64.0) 1248(60.3) 1328(65.3) 1354(66.4)  < 0.001
Dyslipidemia, % 4241 (69.1) 1403(67.8) 1436(70.6) 1402(68.8) 0.140
Family history of CAD, % 1433 (23.3) 501(24.2) 479(23.6) 453(22.2) 0.309
Smoking, % 3496 (56.9) 1197(57.9) 1173(57.7) 1126(55.3) 0.169
Prior MI, % 1219 (19.9) 465(22.5) 394(19.4) 360(17.7)  < 0.001
Prior PCI or CABG, % 1581 (25.7) 621(30.0) 514(25.3) 446(21.9)  < 0.001
Prior stroke, % 658 (10.7) 204(9.9) 206(10.1) 248(12.2) 0.033
Clinical presentation, %  < 0.001
 SAP 2572 (41.9) 995 (48.1) 874 (43.0) 703 (34.5)  
 ACS 3568 (58.1) 1074 (51.9) 1159 (57.0) 1335 (65.5)  
 LVEF, % 63.0 ± 7.2 63.6 ± 6.8 63.5 ± 6.8 62.0 ± 7.9  < 0.001
 FBG, mmol/L 6.1 ± 2.0 5.8 ± 1.8 6.1 ± 2.0 6.3 ± 2.2  < 0.001
 HbA1c, % 6.6 ± 1.2 6.4 ± 1.0 6.6 ± 1.2 6.8 ± 1.4  < 0.001
 FIB, mg/dL 3.40 ± 0.84 2.62 ± 0.28 3.26 ± 0.17 4.32 ± 0.74  < 0.001
 hs-CRP, mg/L 3.14 ± 3.77 1.31 ± 1.74 2.34 ± 2.65 5.81 ± 4.64  < 0.001
 D-dimer, μg/mL 0.41 ± 0.65 0.37 ± 0.70 0.38 ± 0.52 0.48 ± 0.70  < 0.001
 TC, mmol/L 4.17 ± 1.09 4.00 ± 1.07 4.21 ± 1.08 4.30 ± 1.11  < 0.001
 HDL-C, mmol/L 1.02 ± 0.28 1.02 ± 0.27 1.03 ± 0.28 1.00 ± 0.28 0.060
 LDL-C, mmol/L 2.48 ± 0.92 2.34 ± 0.91 2.50 ± 0.91 2.59 ± 0.93  < 0.001
 TG, mmol/L 1.81 ± 1.12 1.75 ± 1.12 1.85 ± 1.13 1.83 ± 1.12 0.015
 Creatinine (μmol/L) 75.4 ± 16.0 74.5 ± 14.1 74.6 ± 15.4 77.0 ± 18.2  < 0.001
 Lesion vessels 1.4 ± 0.7 1.4 ± 0.6 1.4 ± 0.7 1.5 ± 0.7  < 0.001
 LM/three-vessel disease, % 2773 (45.2) 865 (41.8) 909 (44.7) 999 (49.0)  < 0.001
 SYNTAX scorea 12.0 ± 8.2 11.2 ± 7.8 11.9 ± 8.2 12.8 ± 8.5  < 0.001
 Complete revascularization, % 3310 (53.9) 1201 (58.0) 1090 (53.6) 1019 (50.0)  < 0.001
 Number of stents 1.8 ± 1.2 1.8 ± 1.1 1.8 ± 1.2 1.9 ± 1.2 0.148
 DES implantation, % 5778 (94.1) 1941 (93.8) 1923 (94.6) 1914 (93.9) 0.520
Medications at discharge, %
 Aspirin 6077 (99.0) 2051(99.1) 2011(98.9) 2015(98.9) 0.680
 Clopidogrel 6020 (98.0) 2023(97.8) 1997(98.2) 2000(98.1) 0.542
 β-blocker 5609 (91.4) 1878(90.8) 1868(91.9) 1863(91.4) 0.443
 ACEI/ARB 3150 (51.3) 983(47.5) 1049(51.6) 1118(54.9)  < 0.001
 CCB 2875 (46.8) 952(46.0) 973(47.9) 950(46.6) 0.482
 Statin 5923 (96.5) 2002(96.8) 1963(96.6) 1958(96.1) 0.473
 Nitrate 5984 (97.5) 2021(97.7) 1981(97.4) 1982(97.3) 0.683
  1. Values are presented as mean ± standard deviation or number (%)
  2. ACEI angiotensin-converting enzyme inhibitors, ACS acute coronary syndrome, ARB angiotensin II receptor blockers, BMI body mass index, CAD coronary artery disease, CABG coronary artery bypass grafting, CCB calcium channel blocker, DES drug-eluting stent, FIB fibrinogen, FBG fasting blood glucose, hs-CRP high sensitivity C-reactive protein, HbA1c Hemoglobin A1c, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, LM left main disease, LVEF left ventricular ejection fraction, MI myocardial infarction, PCI percutaneous coronary intervention, SAP stable angina pectoris, TC total cholesterol, TG triglycerides
  3. aCalculated using an online calculator (http://www.syntaxscore.com/) by a dedicated research group blinded to the clinical data