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Table 1 Baseline characteristics of patients stratified by tertile of TyG index

From: Triglyceride-glucose index is associated with in-stent restenosis in patients with acute coronary syndrome after percutaneous coronary intervention with drug-eluting stents

  Total (n = 1574) Tertile of TyG index P-value
I (Lowest) (n = 525) II (Median) (n = 533) III (Highest) (n = 516)
   6.55 < TyG  8.58 8.58 < TyG  9.11 9.11 < TyG  10.89  
Age, years 58.40 ± 9.40 59.54 ± 9.23 58.94 ± 9.46 56.67 ± 9.28 < 0.001
Male, n (%) 1218 (77.4) 423 (80.6) 406 (76.2) 389 (75.4) 0.097
BMI, kg/m2 25.96 ± 3.23 25.28 ± 3.06 26.04 ± 3.18 26.57 ± 3.32 < 0.001
LVEF, % 62.17 ± 7.01 62.55 ± 6.61 61.93 ± 7.14 62.04 ± 7.26 0.312
Diagnosis, n (%)      0.061
 UA 1334 (84.8) 459 (87.4) 452 (84.8) 423(82.0)  
 NSTEMI 116 (7.4) 33 (6.3) 44 (8.3) 39 (7.6)  
 STEMI 124 (7.9) 33 (6.3) 37 (6.9) 54 (10.5)  
Medical history, n (%)
 Current smoking 556 (35.3) 173 (33.0) 184 (34.5) 199 (38.6) 0.030
 Hypertension 1016 (64.5) 313 (59.6) 344 (64.5) 359 (69.6) 0.004
 Hypercholesteraemia 610 (38.8) 192 (36.6) 198 (37.1) 220 (42.6) 0.086
 Diabetes mellitus 544 (34.6) 111 (21.1) 173 (32.5) 260 (50.4) < 0.001
 Previous stroke 127 (8.1) 46 (8.8) 43 (8.1) 38 (7.4) 0.710
 Previous PCI 289 (18.4) 95 (18.1) 108 (20.3) 86 (16.7) 0.317
Laboratory tests
 Hs-CRP, mg/L 1.43 (0.56, 3.97) 0.93 (0.40, 3.11) 1.44 (0.59, 3.78) 1.89 (0.82, 4.58) < 0.001
 eGFR, mL/min/1.73 m2 96.54 ± 14.72 96.71 ± 13.93 96.56 ± 14.46 96.34 ± 15.78 0.921
 Uric acid, umol/L 345.49 ± 84.69 332.35 ± 74.62 345.42 ± 81.91 358.92 ± 94.61 < 0.001
 Homocysteine, umol/L 12.50 (9.70, 16.10) 12.80 (9.80, 16.55) 12.70 (9.85, 16.1) 12.00 (9.50, 15.68) 0.095
 FBG, mmol/L 6.57 ± 2.31 5.50 ± 0.97 6.19 ± 1.54 8.04 ± 3.06  < 0.001
 Triglycerides, mmol/L 1.40 (1.02, 1.98) 0.90 ± 0.26 1.47 ± 0.33 2.47 ± 0.88  < 0.001
 TC, mmol/L 4.11 ± 1.07 3.75 ± 0.92 4.09 ± 0.97 4.50 ± 1.17 < 0.001
 HDL-C, mmol/L 1.07 ± 0.24 1.15 ± 0.26 1.06 ± 0.23 0.99 ± 0.21 < 0.001
 LDL-C, mmol/L 2.47 ± 0.89 2.24 ± 0.82 2.51 ± 0.86 2.67 ± 0.93 < 0.001
Angiography
 LM disease, n (%) 139 (8.8) 53 (10.1) 50 (9.4) 36 (7.0) 0.179
 Multivessel/LM disease, n (%) 1195 (75.9) 384 (73.1) 423 (79.4) 388 (75.2) 0.055
 Chronic total occlusion, n (%) 367 (23.3) 104 (19.8) 130 (24.4) 133 (25.8) 0.058
 SYNTAX score 13.93 ± 7.42 13.72 ± 7.83 14.36 ± 7.43 13.70 ± 6.97 0.253
Intervention
 Target vessel, n (%)
  LM 78 (5.0) 30 (5.7) 30 (5.6) 18 (3.5) 0.175
  LAD 889 (56.5) 304 (57.9) 296 (55.5) 289 (56.0) 0.714
  LCX 434 (27.6) 125 (23.8) 151 (28.3) 158 (30.7) 0.042
  RCA 640 (40.7) 214 (40.8) 217 (40.7) 209 (40.5) 0.996
 Intracoronary imagine, n (%) 100 (6.4) 40 (7.6) 31 (5.8) 29 (5.6) 0.343
 DES-sirolimus, n (%) 849 (53.9) 288 (54.9) 281 (52.7) 280 (54.3) 0.772
 DES-zotarolimus, n (%) 345 (21.9) 127 (24.2) 117 (22.0) 101 (19.6) 0.198
 DES-everolimus, n (%) 597 (37.9) 187 (35.6) 210 (39.4) 200 (38.8) 0.400
 Number of stent, /patients 2.00 (1.00, 2.00) 1.00 (1.00, 2.00) 2.00 (1.00, 2.00) 1.00 (1.00, 2.00) 0.227
 Multiple stents (n ≥ 2) 789 (50.1) 256 (48.8) 280 (52.5) 253 (49.0) 0.392
 Length of stents, mm/patients 36 (23, 61) 36 (21, 58.50) 38 (23, 62) 35 (23, 63.75) 0.223
 Minimal stent diameter, mm 2.84 ± 0.46 2.88 ± 0.47 2.83 ± 0.46 2.82 ± 0.46 0.105
Medications at discharge, n (%)
 Aspirin 1574 (100.0) 525 (100.0) 533 (100.0) 516 (100.0) > 0.99
 Clopidogrel/Ticagrelor 1574 (100.0) 525 (100.0) 533 (100.0) 516 (100.0) > 0.99
 Statin 1570 (99.7) 523 (99.6) 532 (99.8) 515 (99.8) 0.779
 β-block 1088 (69.2) 337(64.2) 378 (71.1) 373 (72.3) 0.009
 ACEI/ARB 722 (45.9) 206 (39.2) 250 (46.9) 266 (51.6) < 0.001
 Insulin 174 (11.1) 37 (7.0) 52 (9.8) 85 (16.5) < 0.001
 Other hypoglycemic agents 431 (27.4) 86 (16.4) 133 (25.0) 212 (41.1) < 0.001
  1. TyG: triglyceride-glucose index; BMI: body mass index; LVEF: left ventricular ejection fraction; UA: unstable angina; NSTEMI: non ST-segment elevation myocardial infarction; STEMI: ST-segment elevation myocardial infarction; PCI: percutaneous coronary intervention; Hs-CRP: high sensitivity-C reactive protein; eGFR: estimated glomerular filtration rate; FBG: fasting blood glucose; TC: total cholesterol; HDL-C: high-density lipoprotein-C; LDL-C: low-density lipoprotein-C; LM: left main artery; LAD: left anterior descending artery; LCX: left circumflex artery; RCA: right coronary artery; DES: drug-eluting stent; ACEI/ARB: angiotensin-converting enzyme inhibitor/angiotensin receptor blocker