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Table 2 Cardiac structure and function from echocardiography by diabetes type

From: A cross sectional study to compare cardiac structure and diastolic function in adolescents and young adults with youth-onset type 1 and type 2 diabetes: The SEARCH for Diabetes in Youth Study

  Type 1, n = 258 Type 2, n = 221 Unadjusted p value
Cardiac structure
 LVM Index (g/m2.7), N: median(IQR) 29.2 (24.8: 33.4) 35.9 (30.4: 44.0)  < 0.0001*
 LV relative wall thickness 0.3 (0.1) 0.4 (0.1)  < 0.0001
 Left atrium length (cm) (4 chamber)/BSA 0.2 (0.0) 0.2 (0.0) 0.2536
 Left atrium area (4 chamber)/BSA 0.7 (0.1) 0.7 (0.1) 0.4675
Cardiac function
 Shortening fraction (%) 36.0 ± 5.1 36.2 ± 5.9 0.7046
 Ejection fraction (%) 57.2 ± 7.4 53.4 ± 7.5  < 0.0001*
 Peak longitudinal strain (4 chamber) − 20.6 ± 4.0 − 18.5 ± 3.5  < 0.0001*
 Peak longitudinal strain rate (4 chamber) − 1.0 ± 0.2 − 0.9 ± 0.2  < 0.0001*
 E/A ratio 1.9 ± 0.5 1.6 ± 0.5  < 0.0001*
 E/e' ratio 6.3 ± 1.5 7.6 ± 2.2  < 0.0001*
 e'/a' ratio 1.9 ± 0.6 1.7 ± 0.5  < 0.0001
 Pulse wave velocity m/s 5.9 ± 1.2 8.0 ± 1.7  < 0.0001*
  1. Data are unadjusted mean ± SD, n (%) or median (IQR). Lower is worse except for E/e’ were higher value is worse. * indicates p < 0.05 remains after adjustment for BMI z-score, systolic BP z-score, diastolic BP z-score and hemoglobin A1c. LVM Index, E/A, E/e’, and e’/a’ ratios are log transformed for modeling. After adjustment p value for the difference in RWT was 0.13 and e’/a’ was 0.158