| |
Model 1
|
Model 2
|
|---|
|
HR (95% CI)
|
P-value
|
HR (95% CI)
|
P-value
|
|---|
|
Weight change categories
|
|
Lost > 5%
|
1.19 (0.83–1.71)
|
0.334
|
1.14 (0.79–1.65)
|
0.471
|
|
Lost 3% to 5%
|
0.86 (0.55–1.36)
|
0.526
|
0.76 (0.48–1.20)
|
0.238
|
|
Stable (± 3%)
|
Reference
| |
Reference
| |
|
Gained 3% to 5%
|
0.63 (0.37–1.08)
|
0.096
|
0.66 (0.38–1.15)
|
0.141
|
|
Gained > 5%
|
0.62 (0.41–0.94)
|
0.026
|
0.61 (0.40–0.93)
|
0.021
|
|
Age, year
|
1.04 (1.03–1.05)
|
< 0.001
|
1.04 (1.02–1.05)
|
< 0.001
|
|
Women (men as reference)
|
0.92 (0.70–1.22)
|
0.569
|
0.82 (0.59–1.13)
|
0.216
|
|
BMI, kg/m2
| | |
0.99 (0.96–1.02)
|
0.423
|
|
Educational level, years
|
|
> 12
| | |
Reference
| |
|
6–12
| | |
0.91 (0.50–1.66)
|
0.768
|
|
< 6
| | |
0.92 (0.51–1.69)
|
0.796
|
|
Current smoker, yes
| | |
1.73 (1.06–2.83)
|
0.028
|
|
GLD use, yes
| | |
1.75 (1.27–2.41)
|
0.001
|
|
Family history of premature CVD, yes
| | |
1.08 (0.76–1.52)
|
0.672
|
|
Hypertension, yes
| | |
1.63 (1.22–2.19)
|
0.001
|
|
Hypercholesterolemia, yes
| | |
2.09 (1.43–3.05)
|
< 0.001
|
|
CKD, yes
| | |
0.76 (0.55–1.05)
|
0.099
|
|
FPG, mmol/L
| | |
1.03 (0.99–1.08)
|
0.139
|
- Model 1: adjusted for age and sex. Model 2: Model 1 + further adjusted for BMI, educational level, current smoking (at first follow-up), GLD use (at baseline or first follow-up), family history of premature CVD, hypertension, hypercholesterolemia, CKD, and FPG
- CHD coronary heart disease, BMI body mass index, GLD glucose-lowering drugs, CVD cardiovascular disease, CKD chronic kidney disease, FPG fasting plasma glucose
