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Table 6 Association of TyG with MACE in enrolled patients according to subgroup of characteristics by OCT

From: Triglyceride glucose index combined with plaque characteristics as a novel biomarker for cardiovascular outcomes after percutaneous coronary intervention in ST-elevated myocardial infarction patients: an intravascular optical coherence tomography study

Variables MACE /Total Crude model Adjusted model I Adjust model II Adjust model III
crude HR(95%CI) crude P value Adj I. HR(95%CI) Adj. P value adj. HR(95%CI) Adj. P value adj. HR(95%CI) Adj. P value
Without Macrophage  
 TyG per SD 6 ( 4.8) 0.30(0.10,0.88) 0.029* 0.38(0.12,1.24) 0.083 0.34(0.11,1.07) 0.065 0.36(0.09,1.38) 0.136
 TyGlow 3 (7.1) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference)
 TyGmid 3 (7.3) 1.03 (0.21,5.12) 0.969 1.43 (0.26,8.01) 0.684 1.36 (0.22,8.32) 0.736 4.75 (0.32,70.49) 0.258
 TyGhigh 0 (0) 0.00 (0.00,Inf) 0.999 0.00 (0.00,Inf) 0.999 0.00 (0.00,Inf) 0.998 0.00 (0.00,Inf) 0.999
 Trend test NA 0.43 (0.14,1.35) 0.149 0.54 (0.16,1.83) 0.325 0.45 (0.1,1.97) 0.292 0.60 (0.13,2.79) 0.517
With Macrophage  
 TyG per SD 13 ( 8.7) 0.63(0.35,1.15) 0.131 0.64(0.32,1.25) 0.190 0.52(0.24,1.15) 0.106 0.51(0.23,1.16) 0.111
 TyGlow 5 (10) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference)
 TyGmid 6 (12.2) 1.2 (0.37,3.92) 0.767 1.25 (0.34,4.6) 0.737 0.99(0.23,4.22) 0.990 1.03 (0.23,4.54) 0.972
 TyGhigh 2 (4) 0.36 (0.07,1.86) 0.222 0.38 (0.07,2.18) 0.278 0.32 (0.05,2.12) 0.239 0.31 (0.05,2.12) 0.233
 Trend test NA 0.67 (0.34,1.32) 0.250 0.66 (0.31,1.42) 0.288 0.59 (0.25,1.38) 0.220 0.57 (0.24,1.36) 0.207
Without Calcification  
 TyG per SD 10 ( 7.5) 0.52(0.27,1.02) 0.058 0.48(0.23,1.02) 0.056 0.37(0.16,0.86) 0.021* 0.37(0.15,0.93) 0.035*
 TyGlow 5 (11.1) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference)
 TyGmid 4 (9.1) 0.88 (0.24,3.28) 0.848 0.91 (0.23,3.52) 0.889 1.18 (0.27,5.15) 0.829 1.42 (0.3,6.74) 0.659
 TyGhigh 1 (2.2) 0.19 (0.02,1.66) 0.134 0.20 (0.02,1.77) 0.147 0.08 (0.01,1.02) 0.052 0.11 (0.01,1.41) 0.089
 Trend test NA 0.53 (0.23,1.21) 0.131 0.53 (0.23,1.26) 0.152 0.41 (0.16,1.05) 0.063 0.47 (0.18,1.2) 0.113
With Calcification  
 TyG per SD 9 ( 6.4) 0.55(0.26,1.15) 0.113 0.46(0.17,1.25) 0.129 0.42(0.15,1.18) 0.100 0.41(0.14,1.21) 0.106
 TyGlow 4 (8.5) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference)
 TyGmid 4 (8.7) 0.93 (0.23,3.73) 0.920 0.79 (0.16,3.79) 0.765 0.84 (0.16,4.32) 0.837 0.90 (0.17,4.79) 0.899
 TyGhigh 1 (2.1) 0.23 (0.03,2.07) 0.191 0.23 (0.02,2.38) 0.219 0.18 (0.02,1.98) 0.162 0.20 (0.02,2.41) 0.207
 Trend test NA 0.57 (0.24,1.34) 0.196 0.53 (0.2,1.44) 0.217 0.49 (0.18,1.34) 0.167 0.52 (0.18,1.49) 0.223
Without Micro-calcification  
 TyG per SD 10 ( 7.2) 0.53(0.27,1.04) 0.065 0.50(0.23,1.07) 0.074 0.39(0.17,0.91) 0.028* 0.40(0.16,0.98) 0.043*
 TyGlow 4 (8.7) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference)
 TyGmid 5 (10.9) 1.38 (0.37,5.14) 0.631 1.50 (0.39,5.82) 0.557 1.96 (0.43,8.93) 0.384 2.38 (0.47,11.94) 0.293
 TyGhigh 1 (2.2) 0.25 (0.03,2.21) 0.211 0.26 (0.03,2.47) 0.244 0.13 (0.01,1.63) 0.114 0.17 (0.01,2.29) 0.180
 Trend test NA 0.63 (0.29,1.39) 0.255 0.65 (0.29,1.49) 0.309 0.52 (0.21,1.28) 0.155 0.57 (0.23,1.45) 0.239
With Micro-calcification  
 TyG per SD 9 ( 6.6) 0.54(0.26,1.13) 0.102 0.46(0.17,1.24) 0.124 0.42(0.15,1.20) 0.106 0.41(0.14,1.21) 0.108
 TyGlow 4 (8.9) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference)
 TyGmid 4 (8.9) 0.91 (0.23,3.62) 0.888 0.77 (0.16,3.67) 0.742 0.80 (0.16,4.11) 0.794 0.85 (0.16,4.5) 0.851
 TyGhigh 1 (2.2) 0.22 (0.03,2.01) 0.182 0.23 (0.02,2.39) 0.220 0.18 (0.02,1.99) 0.162 0.20 (0.02,2.33) 0.200
 Trend test NA 0.56 (0.24,1.32) 0.185 0.54 (0.2,1.45) 0.219 0.49 (0.18,1.35) 0.167 0.51 (0.18,1.47) 0.213
Without lipid plaque  
 TyG per SD 9 ( 6.8) 0.36(0.17,0.74) 0.006* 0.40(0.18,0.86) 0.020* 0.19(0.06,0.58) 0.004* 0.20(0.07,0.59) 0.003*
 TyGlow 6 (13.6) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference)
 TyGmid 2 (4.5) 0.32 (0.07,1.6) 0.166 0.3 (0.06,1.58) 0.156 0.31 (0.06,1.70) 0.179 0.22 (0.04,1.29) 0.093
 TyGhigh 1 (2.2) 0.15 (0.02,1.24) 0.078 0.2 (0.02,1.77) 0.149 0.15 (0.02,1.41) 0.097 0.09 (0.01,1.05) 0.055
 Trend test NA 0.37 (0.14,0.98) 0.045* 0.4 (0.14,1.14) 0.085 0.37 (0.13,1.04) 0.058 0.27 (0.09,0.89) 0.031*
With lipid plaque  
 TyG per SD 10 ( 7.1) 0.75(0.38,1.48) 0.402 0.81(0.38,1.72) 0.578 0.71(0.28,1.79) 0.465 0.74(0.29,1.90) 0.536
 TyGlow 2 (4.3) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference)
 TyGmid 7 (14.9) 3.54 (0.73,17.04) 0.115 4.12 (0.79,21.54) 0.094 2.79 (0.46,16.95) 0.265 6.58 (0.76,56.95) 0.087
 TyGhigh 1 (2.1) 0.49 (0.04,5.42) 0.562 0.67 (0.06,7.84) 0.751 0.47 (0.03,6.57) 0.578 0.65 (0.04,10.39) 0.763
 Trend test NA 0.85 (0.4,1.83) 0.683 0.94 (0.4,2.17) 0.878 0.72 (0.27,1.93) 0.513 0.74 (0.28,1.99) 0.557
Without mixed plaque  
 TyG per SD 16 ( 7.5) 0.56(0.33,0.97) 0.040* 0.59(0.32,1.06) 0.078 0.45(0.34,0.88) 0.019* 0.43(0.22,0.84) 0.013*
 TyGlow 7 (9.9) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference)
 TyGmid 7 (9.9) 0.96 (0.34,2.74) 0.939 0.95 (0.29,3.06) 0.925 0.81 (0.24,2.74) 0.736 0.78 (0.22,2.70) 0.691
 TyGhigh 2 (2.8) 0.26 (0.05,1.26) 0.095 0.30 (0.06,1.56) 0.153 0.20 (0.04,1.14) 0.069 0.17 (0.03,0.99) 0.048*
 Trend test NA 0.59 (0.31,1.11) 0.102 0.60 (0.30,1.22) 0.161 0.49 (0.23,1.06) 0.069 0.45 (0.21,0.99) 0.047*
With mixed plaque  
 TyG per SD 3 ( 5.0) - - - - - - - -
 TyGlow 2 (10) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference)
 TyGmid 1 (5) 0.50 (0.05,5.54) 0.574 0.54 (0.05,5.98) 0.612 1.74 (0.07,45.28) 0.738 - 0.998
 TyGhigh 0 (0) 0 (0,Inf) 0.999 0 (0,Inf) 0.999 0 (0,Inf) 0.999 0 (0,Inf) 0.999
 Trend test NA 0.29 (0.04,1.96) 0.203 0.35 (0.05,2.67) 0.311 0.68 (0.07,6.31) 0.735 0.42 (0.02,7.97) 0.563
TCFA = 0  
 TyG per SD 12 ( 5.9) 0.47(0.25,0.87) 0.017* 0.50(0.26,0.98) 0.043* 0.39(0.19,0.82) 0.012* 0.39(0.18,0.84) 0.017*
 TyGlow 6 (8.8) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference)
 TyGmid 5 (7.4) 0.81 (0.25,2.66) 0.731 0.90 (0.25,3.21) 0.875 0.93 (0.25,3.37) 0.908 0.95 (0.25,3.60) 0.934
 TyGhigh 1 (1.4) 0.15 (0.02,1.29) 0.084 0.19 (0.02,1.64) 0.130 0.11 (0.01,1.12) 0.063 0.11 (0.01,1.36) 0.086
 Trend test NA 0.49 (0.23,1.07) 0.073 0.53 (0.23,1.21) 0.132 0.45 (0.19,1.07) 0.071 0.46 (0.18,1.17) 0.104
TCFA = 1  
 TyG per SD 7 (10.1) 0.53(0.22,1.30) 0.164 0.54(0.17,1.72) 0.295 1.12(0.00,298.31) 0.968 Inf(0.00,inf) 0.994
 TyGlow 3 (13) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference) 1(reference)
 TyGmid 3 (13) 0.85 (0.17,4.24) 0.843 0.73 (0.1,5.14) 0.751 0.50 (0.06,4.43) 0.532 1.70 (0.10,28.36) 0.710
 TyGhigh 1 (4.3) 0.26 (0.03,2.56) 0.250 0.36 (0.03,4.46) 0.424 0.25 (0.02,3.35) 0.295 0.56 (0.04,7.69) 0.662
 Trend test NA 0.57 (0.22,1.49) 0.249 0.61 (0.19,2.04) 0.426 0.50 (0.14,1.76) 0.279 0.78 (0.23,2.68) 0.698
  1. Adjust I model adjusts for sex and age; Adjust II model adjusts for adjust I plus ejection fraction, smoke, hypertension, hyperlipidemia, diabetes mellitus and killip classification; Adjust III model adjusts for adjust II + creatine kinase, heart rate and C-reactive protein
  2. HR, hazard ratio; CI, confidence interval; TyG, triglyceride glucose index.SD, Standard deviation; Inf, infinity; NA, Not available
  3. *P < 0.05