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Table 3 Risk of incident PAD for various levels of TyG index trajectory groups

From: Triglyceride-glucose index in the development of peripheral artery disease: findings from the Atherosclerosis Risk in Communities (ARIC) Study

TyG index trajectories

Model 1

OR (95% CI)

P value

Model 2

OR (95% CI)

P value

Model 3

OR (95% CI)

P value

Low

Reference

1.0

Reference

1.0

Reference

1.0

Moderate

1.279 (1.054–1.551)

0.012

1.143 (0.938–1.392)

0.184

1.063 (0.871–1.298)

0.547

High

1.957 (1.604–2.387)

 < 0.001

1.552 (1.258–1.915)

 < 0.001

1.404 (1.132–1.740)

0.002

Very high

3.132 (2.440–4.022)

 < 0.001

1.932 (1.441–2.590)

 < 0.001

1.742 (1.294–2.344)

 < 0.001

  1. Model 1: Adjusted for baseline age, race, and sex
  2. Model 2: Adjusted for model 1 covariates plus baseline antihypertensive medication, body mass index, diabetes, drinking status, education level, leisure time and sport index scores, lipid-lowering medication, systolic blood pressure, and smoking status
  3. Model 3: Adjusted for model 2 covariates plus baseline estimated glomerular filtration rate, factor VIII activity, fibrinogen, low-density lipoprotein cholesterol, von Willebrand factor, and white blood cell count
  4. CI confidence interval, OR odds ratio, HR hazard ratio, PAD peripheral artery disease, TyG triglyceride-glucose
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Cardiovascular Diabetology

ISSN: 1475-2840