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Table 3 Risk of incident PAD for various levels of TyG index trajectory groups

From: Triglyceride-glucose index in the development of peripheral artery disease: findings from the Atherosclerosis Risk in Communities (ARIC) Study

TyG index trajectories Model 1
OR (95% CI)
P value Model 2
OR (95% CI)
P value Model 3
OR (95% CI)
P value
Low Reference 1.0 Reference 1.0 Reference 1.0
Moderate 1.279 (1.054–1.551) 0.012 1.143 (0.938–1.392) 0.184 1.063 (0.871–1.298) 0.547
High 1.957 (1.604–2.387)  < 0.001 1.552 (1.258–1.915)  < 0.001 1.404 (1.132–1.740) 0.002
Very high 3.132 (2.440–4.022)  < 0.001 1.932 (1.441–2.590)  < 0.001 1.742 (1.294–2.344)  < 0.001
  1. Model 1: Adjusted for baseline age, race, and sex
  2. Model 2: Adjusted for model 1 covariates plus baseline antihypertensive medication, body mass index, diabetes, drinking status, education level, leisure time and sport index scores, lipid-lowering medication, systolic blood pressure, and smoking status
  3. Model 3: Adjusted for model 2 covariates plus baseline estimated glomerular filtration rate, factor VIII activity, fibrinogen, low-density lipoprotein cholesterol, von Willebrand factor, and white blood cell count
  4. CI confidence interval, OR odds ratio, HR hazard ratio, PAD peripheral artery disease, TyG triglyceride-glucose