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Table 2 Risk of incident PAD for baseline TyG index

From: Triglyceride-glucose index in the development of peripheral artery disease: findings from the Atherosclerosis Risk in Communities (ARIC) Study

TyG index Events/No. at risk Model 1
HR (95% CI)
P value Model 2
HR (95% CI)
P value Model 3
HR (95% CI)
P value
Quartile 1 222/3080 Reference 1.0 Reference 1.0 Reference 1.0
Quartile 2 278/3080 1.290 (1.081–1.538) 0.005 1.097 (0.918–1.312) 0.307 1.040 (0.869–1.245) 0.666
Quartile 3 359/3080 1.671 (1.413–1.975)  < 0.001 1.301 (1.094–1.546) 0.003 1.208 (1.013–1.441) 0.035
Quartile 4 441/3080 2.232 (1.900–2.623)  < 0.001 1.339 (1.116–1.606) 0.002 1.239 (1.028–1.492) 0.024
Per 1 SD (0.58) 1300/12320 1.403 (1.332–1.478)  < 0.001 1.148 (1.078–1.222)  < 0.001 1.119 (1.049–1.195) 0.001
  1. Model 1: Adjusted for baseline age, race, and sex
  2. Model 2: Adjusted for model 1 covariates plus baseline antihypertensive medication, body mass index, diabetes, drinking status, education level, leisure time and sport index scores, lipid-lowering medication, systolic blood pressure, and smoking status
  3. Model 3: Adjusted for model 2 covariates plus baseline estimated glomerular filtration rate, factor VIII activity, fibrinogen, low-density lipoprotein cholesterol, von Willebrand factor, and white blood cell count
  4. CI confidence interval, HR hazard ratio, PAD peripheral artery disease, TyG triglyceride-glucose