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Table 2 Relation between ANGPTL8 and kidney function decline, according to quartiles of ANGPTL8

From: Circulating ANGPTL8 levels and risk of kidney function decline: Results from the 4C Study

ANGPTL8 Model 1 Model 2 Model 3 IPTW model
Q1 (Reference) 1 1 1  
Q2 (HR, 95% CI) 1.91 (1.04–3.51) 1.86 (0.98–3.54) 1.52 (0.79–2.94) 1.72 (1.10–2.68)
Q3 (HR, 95% CI) 1.74 (0.93–3.25) 1.45 (0.74–2.85) 1.43 (0.73–2.80) 1.36 (0.86–2.14)
Q4 (HR, 95% CI) 4.66 (2.70–8.05) 3.99 (2.21–7.20) 2.59 (1.41–4.77) 1.73 (1.27–2.36)
Per-SD increase 1.64 (1.45–1.85) 1.55 (1.36–1.77) 1.31 (1.13–1.51) -
  1. Model 1 was unadjusted
  2. Model 2 was adjusted for age, sex and BMI
  3. Model 3 was adjusted for all variables in model 2 plus baseline eGFR, HDL, LDL, TC, TG, ALT, AST, history of diabetes, hypertension and CVD at baseline
  4. HR hazards ratio, CI confidence intervals, IPTW inverse possibility of treatment weight, SD standard deviation