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Table 2 Physical and conventional echocardiographic parameters in normal and Ang II-infused rats treated with vehicle or DAPA

From: Dapagliflozin: a sodium–glucose cotransporter 2 inhibitor, attenuates angiotensin II-induced cardiac fibrotic remodeling by regulating TGFβ1/Smad signaling

Parameters

CTL

CTL + DAPA

Ang II

Ang II + DAPA

BW (g)

362.17 ± 12.67

358 ± 9.93

320.33 ± 15.31*

318.5 ± 12.29*

SBP (mmHg)

131.95 ± 13.49

134.4 ± 16.43

228.28 ± 14.62*

222.67 ± 19.34*

DBP (mmHg)

102.6 ± 16.62

106.77 ± 11.2

190.02 ± 18.49*

173.1 ± 17.58*

HW (g)

1.0 ± 0.08

1.03 ± 0.07

1.33 ± 0.05*

1.14 ± 0.1*

LVW (g)

0.71 ± 0.07

0.71 ± 0.08

1.0 ± 0.03*

0.85 ± 0.07*

IVSd (mm)

1.83 ± 0.08

1.82 ± 0.06

2.5 ± 0.14*

1.85 ± 0.09

LVEDd (mm)

7.45 ± 0.65

7.49 ± 0.19

6.28 ± 0.42*

7.06 ± 0.71

LVEDs (mm)

4.49 ± 0.26

4.37 ± 0.23

3.37 ± 0.23*

4.0 ± 0.5*

LVPWd (mm)

1.68 ± 0.1

1.74 ± 0.13

2.32 ± 0.13*

1.73 ± 0.12

LVEDV (ml)

0.94 ± 0.22

0.92 ± 0.05

0.58 ± 0.1*

0.81 ± 0.24

LVESV (ml)

0.22 ± 0.04

0.2 ± 0.02

0.1 ± 0.02*

0.17 ± 0.07*

LVEF (%)

75.47 ± 3.21

78.02 ± 2.57

82.88 ± 0.79*

79.9 ± 1.99*

LVFS (%)

39.51 ± 2.83

40.61 ± 1.41

46.32 ± 0.85*

43.46 ± 1.79*

HR

389.48 ± 21.59

377.53 ± 17.21

409.01 ± 26.04

409.32 ± 21.06

  1. Values are presented as mean ± SD (n = 6 rats per group)
  2. Data are expressed as the mean ± SD
  3. BW body weight, SBP systolic blood pressure, DBP diastolic blood pressure, HW heart weight, LVW left ventricle weight, TL tibia length, IVSd end-diastole interventricular septum thickness, LVEDd left ventricular end-diastolic dimension, LVEDs left ventricular end-systolic dimension, LVEDV left ventricular end-diastolic volume, LVESV left ventricular end-systolic volume, LVPWd diastolic left ventricular posterior wall thickness, LVFS left ventricular fractional shortening, LVEF the left ventricular ejection fraction, HR heart rate
  4. *P < 0.05 relative to CTL group
  5. P < 0.05 relative to Ang II group