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Table 5 Changes induced by weight loss according to glucose tolerance

From: High plasma renin activity associates with obesity-related diabetes and arterial hypertension, and predicts persistent hypertension after bariatric surgery

 

All

p ^

NGT

p ^

IGT

p ^

T2DM

p ^

Δ Weight

− 21.7 ± 13.0

< 0.0001

− 22.2 ± 11.9

< 0.0001

− 21.4 ± 15.6

< 0.0001

− 18.6 ± 10.6

< 0.0001

Δ BMI

− 8.1 ± 4.5

< 0.0001

− 8.0 ± 4.1

< 0.0001

− 8.2 ± 5.4

< 0.0001

− 7.9 ± 4.1

< 0.0001

Δ WC

− 15.4 ± 10.1

< 0.0001

− 16.5 ± 9.5

< 0.0001

− 13.6 ± 11.8

< 0.0001

− 13.2 ± 8.3

< 0.0001

Δ FPG

− 15.6 ± 25.8

< 0.0001

− 8.7 ± 15.8

< 0.0001

− 13.7 ± 17.5

< 0.0001

− 45.5 ± 45.5

< 0.0001

Δ 1hPG

− 36.7 ± 48.8

< 0.0001

− 23.4 ± 45.8

< 0.0001

− 48.4 ± 47.2

< 0.0001

− 62.5 ± 46.5

< 0.0001

Δ 2hPG

− 34.7 ± 53.9

< 0.0001*

− 6.2 ± 34.2

0.1018*

− 46.5 ± 40.4

< 0.0001*

− 113.5 ± 53.7

< 0.0001*

Δ Insulin

− 8.6 ± 9.7

< 0.0001

− 9.5 ± 11.2

< 0.0001

− 6.9 ± 7.2

< 0.0001

− 9.1 ± 8.2

< 0.0001

Δ HOMA-IR

− 2.8 ± 3.3

< 0.0001

− 2.6 ± 3.2

< 0.0001

− 2.3 ± 2.4

< 0.0001

− 4.8 ± 4.2

< 0.0001

Δ HbA1c

− 0.6 ± 1.0

< 0.0001

− 0.3 ± 0.6

< 0.0001

− 0.5 ± 0.7

< 0.0001

− 1.7 ± 1.7

< 0.0001

Δ Total chol

1.7 ± 30.7

0.4949*

0.0 ± 29.8

0.9971*

− 0.2 ± 31.7

0.9711*

10.2 ± 30.1

0.1458*

Δ HDL-chol

6.3 ± 9.8

< 0.0001*

6.9 ± 9.7

< 0.0001*

5.4 ± 9.7

0.0006*

5.2 ± 9.9

0.0386*

Δ Triglycerides

− 41.2 ± 68.9

< 0.0001

− 34.6 ± 59.6

< 0.0001

− 35.2 ± 54.5

< 0.0001

− 76.5 ± 104.9

0.0019

Δ Systolic BP

− 5.2 ± 14.7

0.0001

− 6.1 ± 15.5

0.0007

− 1.4 ± 11.4

0.5372

− 11.6 ± 17.4

0.0212

Δ Diastolic BP

− 3.2 ± 11.2

0.0014

− 3.8 ± 10.8

0.0052

0.0 ± 10.6

0.9073

− 8.8 ± 12.6

0.0114

Δ Creatinine

0.0 ± 0.1

0.2882

0.0 ± 0.1

0.9522

0.0 ± 0.1

0.2774

0.0 ± 0.1

1.0000

Δ Leptin

− 17.7 ± 12.8

< 0.0001*

− 17.1 ± 9.4

< 0.0001*

− 21.1 ± 16.4

< 0.0001*

− 6.3 ± 4.8

0.0781*

Δ Ferritin

− 16.2 ± 76.6

0.0164

− 18 ± 44.7

0.0095

− 7.4 ± 43.3

0.5239

− 31.1 ± 190.6

1.0000

Δ Transferrin

− 0.0 ± 0.4

0.3279

− 0.0 ± 0.4

0.7014

− 0.0 ± 0.5

0.5159

− 0.1 ± 0.4

0.4132

Δ Iron

1.8 ± 28.7

0.4731

2.2 ± 30.0

0.5303

3.6 ± 27.2

0.3900

− 3.7 ± 27.8

0.5529

Δ Albumin

− 0.1 ± 3.8

0.8788

0.3 ± 3.8

0.4367

− 0.5 ± 4.2

0.4401

− 0.6 ± 2.9

0.3637

Δ Calcium

0.0 ± 0.1

0.0055*

0.0 ± 0.1

0.0099*

0.0 ± 0.1

0.1731*

0.0 ± 0.1

0.8552*

Δ Sodium

0.8 ± 3.0

0.0014*

0.5 ± 3.2

0.1291*

1.1 ± 2.4

0.0039*

1.5 ± 2.9

0.0321*

Δ Supine PRA

− 0.9 ± 4.5

0.0035

− 0.4 ± 3.8

0.0067

− 1.1 ± 4.7

0.2947

− 3.1 ± 7.0

0.5195

Δ Upright PRA

− 1.0 ± 7.9

0.1821

0.0 ± 7.2

0.5256

− 1.5 ± 5.5

0.2745

− 5.0 ± 14.5

0.5186

Δ Supine ALD

− 0.6 ± 4.3

0.0005

− 0.7 ± 5.3

0.0016

− 0.4 ± 2.0

0.2624

− 1.0 ± 2.8

0.2439

Δ Upright ALD

− 0.4 ± 8.7

0.0439

0.0 ± 10.3

0.1674

− 0.1 ± 4.5

0.5056

− 3.1 ± 8.1

0.1099

Δ Upright A/PRA

− 0.5 ± 8.7

0.8917

− 0.1 ± 9.3

0.8980

− 0.5 ± 7.0

0.2851

− 2.9 ± 9.9

0.3804

Δ Urinary cortisol

− 15.9 ± 56.3

0.0170*

− 21.5 ± 49.9

0.0060*

− 9.7 ± 68.8

0.5379*

− 3.1 ± 58.8

0.8714*

Δ Uric acid

− 0.4 ± 1.1

< 0.0001*

− 0.5 ± 1.1

< 0.0001*

− 0.4 ± 1.1

0.0138*

− 0.2 ± 1.5

0.5167*

Δ Hypoglycemica

0.0 ± 1.2

1.0000

0.0 ± 0.0

 N.E

0.1 ± 0.5

1.0000

− 0.2 ± 3.4

1.0000

  1. −  indicates decrease
  2. NGT normal glucose tolerance, IGT impaired glucose tolerance, T2D type 2 diabetes, BMI body mass index, WC waist circumference, FPG fasting plasma glucose, 1hPG 1-hour plasma glucose, 2hPG 2-hour plasma glucose, BP blood pressure, PRA plasma renin activity, ALD aldosterone, ALD/PRA Upright A/PRA, N.E not estimable
  3. ^Non-parametric Wilcoxon signed rank test for paired data
  4. *Paired T test
  5. aPills per day
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Cardiovascular Diabetology

ISSN: 1475-2840