The TRIB3 R84 variant is associated with increased left ventricular mass in a sample of 2426 White individuals

Table 2 Echocardiographic parameters of the study subjects stratified according to TRB3 genotypes

Variables	Whole study group	Q84Q	Q84R	R84R	P	P Q84R vs. Q84Q	P R84R vs. Q84Q
LV end-diastolic diameter (LVEDD) (cm)	4.94 ± 0.55	4.93 ± 0.54	4.96 ± 0.57	5.07 ± 0.61	0.09	0.39	0.04
LV end-diastolic volume (LVEDVI) (ml/m²)	66.9 ± 21.1	66.4 ± 20.0	68.1 ± 23.2	72.8 ± 28.3	0.05	0.24	0.02
Interventricular septal thickness (IVS) (cm)	1.08 ± 0.19	1.07 ± 0.19	1.09 ± 0.20	1.12 ± 0.18	0.173	0.284	0.104
Posterior wall thickness (PWT) (cm)	0.91 ± 0.16	0.90 ± 0.16	0.92 ± 0.18	0.96 ± 0.16	0.020	0.134	0.013
LV mass (g)	206 ± 66	203 ± 62	211 ± 74	232 ± 85	< 0.0001	0.032	< 0.0001
LV mass index (LVMI) (g/m²)	109 ± 32	108 ± 30	113 ± 35	125 ± 44	< 0.0001	0.033	< 0.0001
E/A ratio	0.98 ± 0.35	0.98 ± 0.34	0.98 ± 0.39	0.88 ± 0.20	0.198	0.458	0.117
Ejection fraction (%)	71 ± 8	71 ± 7	71 ± 8	70 ± 8	0.375	0.365	0.253

Data are means ± SD. Differences of continuous variables between groups were tested by a general linear model with post hoc Fisher's least significant difference correction for pairwise comparisons. P values refer to results after adjustment for age, and sex. LV left ventricular

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