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Table 5 Multivariable stepwise logistic regression model for presence of unstable plaques

From: Association between carotid plaque vulnerability and high mobility group box-1 serum levels in a diabetic population

 

Variable OR (95% CI)

p value

Model 1

 Sex

1.12 (0.95–1.14)

0.206

 Age

1.24 (1.09–1.32)

0.182

 Smoking (current)

22.3 (3.98–87.1)

0.001

 Smoking (former)

1.44 (1.12–1.53)

0.185

 Hypertension

21.1 (5.45–64.1)

< 0.001

 Hypercholesterolemia

7.21 (2.34–17.9)

0.021

 Triglycerides

0.64 (0.23–1.24)

0.041

 LDL-C

9.31 (1.62–53.1)

0.023

 Hs-CRP

29.5 (9.08–86.4)

< 0.001

 IL-6

6.76 (2.37–15.8)

0.001

Model 2

 Sex

0.89 (0.20–0.97)

0.096

 Age

1.33 (1.04–1.72)

0.216

 Smoking (current)

46.4 (4.24–165.5)

0.001

 Smoking (former)

1.34 (1.09–1.57)

0.212

 Hypertension

29.3 (4.87–143.3)

< 0.001

 Hypercholesterolemia

8.34 (2.06–39.6)

0.011

 Triglycerides

0.91 (0.45–1.79)

0.003

 LDL-C

21.3 (3.58–149.5)

0.012

 Hs-CRP

65.4 (9.33–196.3)

< 0.001

 IL-6

7.69 (2.92–18.91)

< 0.001

 OPG

4.34 (1.98–5.89)

0.021

 HMGB1

19.6 (4.75–27.39)

0.015

  1. Model 1: adjusted for traditional cardiovascular risk factors and established inflammatory cytokines
  2. Model 2: adjusted for the risk factors in model 1 plus high-mobility group box 1 (HMGB1) and osteoprotegerin (OPG)