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Table 5 Multivariable stepwise logistic regression model for presence of unstable plaques

From: Association between carotid plaque vulnerability and high mobility group box-1 serum levels in a diabetic population

  Variable OR (95% CI) p value
Model 1
 Sex 1.12 (0.95–1.14) 0.206
 Age 1.24 (1.09–1.32) 0.182
 Smoking (current) 22.3 (3.98–87.1) 0.001
 Smoking (former) 1.44 (1.12–1.53) 0.185
 Hypertension 21.1 (5.45–64.1) < 0.001
 Hypercholesterolemia 7.21 (2.34–17.9) 0.021
 Triglycerides 0.64 (0.23–1.24) 0.041
 LDL-C 9.31 (1.62–53.1) 0.023
 Hs-CRP 29.5 (9.08–86.4) < 0.001
 IL-6 6.76 (2.37–15.8) 0.001
Model 2
 Sex 0.89 (0.20–0.97) 0.096
 Age 1.33 (1.04–1.72) 0.216
 Smoking (current) 46.4 (4.24–165.5) 0.001
 Smoking (former) 1.34 (1.09–1.57) 0.212
 Hypertension 29.3 (4.87–143.3) < 0.001
 Hypercholesterolemia 8.34 (2.06–39.6) 0.011
 Triglycerides 0.91 (0.45–1.79) 0.003
 LDL-C 21.3 (3.58–149.5) 0.012
 Hs-CRP 65.4 (9.33–196.3) < 0.001
 IL-6 7.69 (2.92–18.91) < 0.001
 OPG 4.34 (1.98–5.89) 0.021
 HMGB1 19.6 (4.75–27.39) 0.015
  1. Model 1: adjusted for traditional cardiovascular risk factors and established inflammatory cytokines
  2. Model 2: adjusted for the risk factors in model 1 plus high-mobility group box 1 (HMGB1) and osteoprotegerin (OPG)