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Table 3 Bonferroni significant results of the proteome-wide analysis with incident MetS in KORA (N = 623), sorted by the magnitude of the OR

From: Metabolic syndrome and the plasma proteome: from association to causation

Target full name UniProt Gene symbol OR (CI) P-value
Plasminogen activator inhibitor 1 P05121 SERPINE1 1.82 (1.46–2.30) 2.28E−07
Growth hormone receptor P10912 GHR 1.65 (1.33–2.04) 4.63E−06
Aminoacylase-1 Q03154 ACY1 1.64 (1.30–2.09) 4.02E−05
C5a anaphylatoxin P01031 C5 1.62 (1.32–2.01) 6.52E−06
Adiponectin Q15848 ADIPOQ 0.55 (0.43–0.70) 1.83E−06
Insulin-like growth factor-binding protein 2 P18065 IGFBP2 0.55 (0.44–0.68) 8.36E−08
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 Q8TEU8 WFIKKN2 0.58 (0.46–0.73) 4.09E−06
Netrin receptor UNC5D Q6UXZ4 UNC5D 0.61 (0.48–0.77) 2.82E−05
Sex hormone-binding globulin P04278 SHBG 0.61 (0.49–0.77) 3.43E−05
Iduronate 2-sulfatase P22304 IDS 0.63 (0.50–0.77) 1.84E−05
Hepatocyte growth factor receptor P08581 MET 0.63 (0.50–0.77) 1.78E−05
Advanced glycosylation end product-specific receptor, soluble Q15109 AGER 0.63 (0.51–0.77) 1.10E−05
Insulin-like growth factor-binding protein 1 P08833 IGFBP1 0.63 (0.51–0.79) 4.26E−05
Interleukin-1 receptor type 1 P14778 IL1R1 0.64 (0.52–0.79) 2.64E−05
  1. All analyses were adjusted for age, sex, smoking status and physical activity
  2. OR; odds ratio per 1 SD increase in log-transformed protein levels