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Table 2 Replicated results of the proteome-wide analysis of prevalent MetS in KORA and HUNT, sorted by the magnitude of the OR in KORA

From: Metabolic syndrome and the plasma proteome: from association to causation

Protein full name

UniProt

Gene symbol

KORA (n = 998)

HUNT (n = 923)

OR (95% CI)

P-value

OR (95% CI)

P-value

Leptin

P41159

LEP

3.70 (2.95–4.70)

4.77E-28

1.76 (1.49–2.08)

3.76E−11

Plasminogen activator inhibitor 1

P05121

SERPINE1

2.51 (2.12–3.00)

2.24E−25

1.37 (1.19–1.57)

9.99E−06

Growth hormone receptor

P10912

GHR

2.33 (1.97–2.78)

3.84E−22

2.08 (1.76–2.47)

9.44E−18

Tissue-type plasminogen activator

P00750

PLAT

2.17 (1.82–2.61)

1.54E−17

1.36 (1.19–1.57)

8.57E−06

Aminoacylase-1

Q03154

ACY1

2.16 (1.83–2.56)

2.95E−19

1.93 (1.64–2.30)

2.71E−14

Dickkopf-like protein 1

Q9UK85

DKKL1

1.96 (1.63–2.39)

6.02E−12

1.31 (1.15–1.51)

9.54E−05

Galectin-3-binding protein

Q08380

LGALS3BP

1.85 (1.59–2.16)

3.66E−15

1.52 (1.32–1.75)

6.81E−09

GDNF family receptor alpha-1

P56159

GFRA1

1.78 (1.52–2.09)

7.06E−13

1.46 (1.27–1.70)

1.99E−07

Complement factor H

P08603

CFH

1.76 (1.51–2.06)

1.44E−12

1.67 (1.42–1.98)

7.71E−10

Apolipoprotein E (isoform E3)

P02649

APOE

1.73 (1.49–2.02)

1.17E−12

1.47 (1.26–1.72)

1.16E−06

Retinoic acid receptor responder protein 2

Q99969

RARRES2

1.72 (1.48–2.01)

3.04E−12

1.54 (1.33–1.80)

1.84E−08

Endoplasmic reticulum resident protein 29

P30040

ERP29

1.71 (1.46–2.00)

1.39E−11

1.40 (1.21–1.61)

3.97E−06

Complement factor I

P05156

CFI

1.70 (1.46–2.00)

1.81E−11

1.36 (1.18–1.58)

2.72E−05

Proto-oncogene tyrosine-protein kinase receptor

P07949

RET

1.70 (1.46–1.99)

1.19E−11

1.87 (1.59–2.21)

1.71E−13

Bone morphogenetic protein 1

P13497

BMP1

1.68 (1.44–1.97)

8.25E−11

1.40 (1.17–1.68)

2.66E−04

Afamin

P43652

AFM

1.66 (1.43–1.93)

4.89E−11

1.37 (1.19–1.58)

1.28E−05

Reticulon-4 receptor

Q9BZR6

RTN4R

1.65 (1.42–1.92)

7.45E−11

1.65 (1.42–1.92)

6.57E−11

Scavenger receptor cysteine-rich type 1 protein M130

Q86VB7

CD163

1.59 (1.38–1.85)

5.75E−10

1.41 (1.23–1.62)

8.61E−07

C–C motif chemokine 25

O15444

CCL25

1.57 (1.36–1.82)

1.04E−09

1.33 (1.15–1.53)

7.50E−05

E-selectin

P16581

SELE

1.56 (1.34–1.82)

1.29E−08

1.68 (1.45–1.94)

3.29E−12

Ficolin-3

O75636

FCN3

1.52 (1.30–1.77)

1.15E−07

1.31 (1.13–1.52)

3.72E−04

Lysosomal protective protein

P10619

CTSA

1.51 (1.31–1.76)

4.55E−08

1.29 (1.12–1.49)

4.00E−04

Cathepsin Z

Q9UBR2

CTSZ

1.49 (1.29–1.73)

9.24E−08

1.42 (1.24–1.65)

1.35E−06

Thrombospondin-2

P35442

THBS2

1.43 (1.24–1.65)

7.57E−07

1.38 (1.20–1.60)

1.33E−05

C–C motif chemokine 16

O15467

CCL16

1.42 (1.21–1.68)

3.69E−05

1.34 (1.16–1.55)

5.95E−05

Insulin-like growth factor-binding protein 2

P18065

IGFBP2

0.33 (0.27–0.39)

4.63E−33

0.52 (0.44–0.62)

4.04E−14

Sex hormone-binding globulin

P04278

SHBG

0.42 (0.35–0.50)

6.47E−22

0.47 (0.40–0.56)

2.86E−18

Insulin-like growth factor-binding protein 1

P08833

IGFBP1

0.43 (0.37–0.51)

1.03E−23

0.55 (0.47–0.64)

1.98E−14

Endothelial cell-specific molecule 1

Q9NQ30

ESM1

0.47 (0.39–0.56)

1.20E−16

0.68 (0.57–0.80)

1.31E−05

Netrin receptor UNC5D

Q6UXZ4

UNC5D

0.48 (0.40–0.56)

8.72E−18

0.75 (0.64–0.87)

1.92E−04

WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2

Q8TEU8

WFIKKN2

0.48 (0.41–0.57)

2.52E−18

0.65 (0.56–0.75)

3.52E−09

Brevican core protein

Q96GW7

BCAN

0.50 (0.42–0.59)

4.72E−15

0.61 (0.51–0.73)

1.87E−07

Neural cell adhesion molecule 1, 120 kDa isoform

P13591

NCAM1

0.51 (0.44–0.60)

6.01E−17

0.63 (0.54–0.73)

1.10E−09

Tumor necrosis factor-inducible gene 6 protein

P98066

TNFAIP6

0.51 (0.44–0.60)

2.05E−15

0.65 (0.56–0.75)

5.30E−09

Wnt inhibitory factor 1

Q9Y5W5

WIF1

0.52 (0.43–0.62)

2.39E−12

0.76 (0.66–0.88)

1.62E−04

Hepatocyte growth factor receptor

P08581

MET

0.52 (0.44–0.60)

1.22E−16

0.73 (0.63–0.85)

4.76E−05

Osteomodulin

Q99983

OMD

0.53 (0.45–0.62)

2.38E−14

0.75 (0.65–0.87)

1.21E−04

Transforming growth factor beta receptor type 3

Q03167

TGFBR3

0.53 (0.45–0.62)

9.27E−16

0.72 (0.62–0.84)

1.78E−05

Mast/stem cell growth factor receptor Kit

P10721

KIT

0.56 (0.47–0.65)

9.54E−13

0.74 (0.64–0.86)

5.65E−05

Gelsolin

P06396

GSN

0.57 (0.49–0.67)

1.83E−12

0.66 (0.57–0.76)

3.50E−08

Iduronate 2-sulfatase

P22304

IDS

0.59 (0.51–0.69)

2.21E−11

0.76 (0.65–0.87)

1.70E−04

72 kDa type IV collagenase

P08253

MMP2

0.60 (0.51–0.69)

2.09E−11

0.64 (0.56–0.74)

3.08E−09

Neural cell adhesion molecule L1-like protein

O00533

CHL1

0.60 (0.51–0.69)

2.41E−11

0.73 (0.63–0.83)

6.26E−06

Epidermal growth factor receptor

P00533

EGFR

0.60 (0.51–0.70)

7.17E−11

0.73 (0.62–0.86)

2.28E−04

Interleukin-1 Receptor accessory protein

Q9NPH3

IL1RAP

0.60 (0.51–0.70)

1.61E−10

0.71 (0.62–0.82)

1.61E−06

Apolipoprotein B

P04114

APOB

0.60 (0.52–0.69)

9.93E−12

0.77 (0.67–0.88)

1.66E−04

Neurogenic locus notch homolog protein 1

P46531

NOTCH1

0.61 (0.52–0.70)

4.64E−11

0.77 (0.67–0.88)

1.63E−04

Plasma protease C1 inhibitor

P05155

SERPING1

0.61 (0.53–0.71)

3.89E−11

0.66 (0.56–0.77)

1.80E−07

Chordin-like protein 1

Q9BU40

CHRDL1

0.67 (0.57–0.79)

2.86E−06

0.72 (0.60–0.86)

4.50E−04

Thrombin

P00734

F2

0.68 (0.57–0.81)

2.65E−05

0.65 (0.55–0.75)

4.13E−08

Kallikrein-8

O60259

KLK8

0.72 (0.62–0.83)

5.94E−06

0.79 (0.69–0.90)

4.12E−04

Superoxide dismutase [Mn], mitochondrial

P04179

SOD2

0.73 (0.63–0.84)

2.42E−05

0.74 (0.64–0.85)

3.13E−05

Muellerian-inhibiting factor

P03971

AMH

0.74 (0.64–0.85)

4.28E−05

0.77 (0.66–0.88)

4.05E−04

  1. All analyses were adjusted for age, sex, smoking status and physical activity
  2. OR; odds ratio per 1 SD increase in log-transformed protein levels
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Cardiovascular Diabetology

ISSN: 1475-2840