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Table 2 Replicated results of the proteome-wide analysis of prevalent MetS in KORA and HUNT, sorted by the magnitude of the OR in KORA

From: Metabolic syndrome and the plasma proteome: from association to causation

Protein full name UniProt Gene symbol KORA (n = 998) HUNT (n = 923)
OR (95% CI) P-value OR (95% CI) P-value
Leptin P41159 LEP 3.70 (2.95–4.70) 4.77E-28 1.76 (1.49–2.08) 3.76E−11
Plasminogen activator inhibitor 1 P05121 SERPINE1 2.51 (2.12–3.00) 2.24E−25 1.37 (1.19–1.57) 9.99E−06
Growth hormone receptor P10912 GHR 2.33 (1.97–2.78) 3.84E−22 2.08 (1.76–2.47) 9.44E−18
Tissue-type plasminogen activator P00750 PLAT 2.17 (1.82–2.61) 1.54E−17 1.36 (1.19–1.57) 8.57E−06
Aminoacylase-1 Q03154 ACY1 2.16 (1.83–2.56) 2.95E−19 1.93 (1.64–2.30) 2.71E−14
Dickkopf-like protein 1 Q9UK85 DKKL1 1.96 (1.63–2.39) 6.02E−12 1.31 (1.15–1.51) 9.54E−05
Galectin-3-binding protein Q08380 LGALS3BP 1.85 (1.59–2.16) 3.66E−15 1.52 (1.32–1.75) 6.81E−09
GDNF family receptor alpha-1 P56159 GFRA1 1.78 (1.52–2.09) 7.06E−13 1.46 (1.27–1.70) 1.99E−07
Complement factor H P08603 CFH 1.76 (1.51–2.06) 1.44E−12 1.67 (1.42–1.98) 7.71E−10
Apolipoprotein E (isoform E3) P02649 APOE 1.73 (1.49–2.02) 1.17E−12 1.47 (1.26–1.72) 1.16E−06
Retinoic acid receptor responder protein 2 Q99969 RARRES2 1.72 (1.48–2.01) 3.04E−12 1.54 (1.33–1.80) 1.84E−08
Endoplasmic reticulum resident protein 29 P30040 ERP29 1.71 (1.46–2.00) 1.39E−11 1.40 (1.21–1.61) 3.97E−06
Complement factor I P05156 CFI 1.70 (1.46–2.00) 1.81E−11 1.36 (1.18–1.58) 2.72E−05
Proto-oncogene tyrosine-protein kinase receptor P07949 RET 1.70 (1.46–1.99) 1.19E−11 1.87 (1.59–2.21) 1.71E−13
Bone morphogenetic protein 1 P13497 BMP1 1.68 (1.44–1.97) 8.25E−11 1.40 (1.17–1.68) 2.66E−04
Afamin P43652 AFM 1.66 (1.43–1.93) 4.89E−11 1.37 (1.19–1.58) 1.28E−05
Reticulon-4 receptor Q9BZR6 RTN4R 1.65 (1.42–1.92) 7.45E−11 1.65 (1.42–1.92) 6.57E−11
Scavenger receptor cysteine-rich type 1 protein M130 Q86VB7 CD163 1.59 (1.38–1.85) 5.75E−10 1.41 (1.23–1.62) 8.61E−07
C–C motif chemokine 25 O15444 CCL25 1.57 (1.36–1.82) 1.04E−09 1.33 (1.15–1.53) 7.50E−05
E-selectin P16581 SELE 1.56 (1.34–1.82) 1.29E−08 1.68 (1.45–1.94) 3.29E−12
Ficolin-3 O75636 FCN3 1.52 (1.30–1.77) 1.15E−07 1.31 (1.13–1.52) 3.72E−04
Lysosomal protective protein P10619 CTSA 1.51 (1.31–1.76) 4.55E−08 1.29 (1.12–1.49) 4.00E−04
Cathepsin Z Q9UBR2 CTSZ 1.49 (1.29–1.73) 9.24E−08 1.42 (1.24–1.65) 1.35E−06
Thrombospondin-2 P35442 THBS2 1.43 (1.24–1.65) 7.57E−07 1.38 (1.20–1.60) 1.33E−05
C–C motif chemokine 16 O15467 CCL16 1.42 (1.21–1.68) 3.69E−05 1.34 (1.16–1.55) 5.95E−05
Insulin-like growth factor-binding protein 2 P18065 IGFBP2 0.33 (0.27–0.39) 4.63E−33 0.52 (0.44–0.62) 4.04E−14
Sex hormone-binding globulin P04278 SHBG 0.42 (0.35–0.50) 6.47E−22 0.47 (0.40–0.56) 2.86E−18
Insulin-like growth factor-binding protein 1 P08833 IGFBP1 0.43 (0.37–0.51) 1.03E−23 0.55 (0.47–0.64) 1.98E−14
Endothelial cell-specific molecule 1 Q9NQ30 ESM1 0.47 (0.39–0.56) 1.20E−16 0.68 (0.57–0.80) 1.31E−05
Netrin receptor UNC5D Q6UXZ4 UNC5D 0.48 (0.40–0.56) 8.72E−18 0.75 (0.64–0.87) 1.92E−04
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 Q8TEU8 WFIKKN2 0.48 (0.41–0.57) 2.52E−18 0.65 (0.56–0.75) 3.52E−09
Brevican core protein Q96GW7 BCAN 0.50 (0.42–0.59) 4.72E−15 0.61 (0.51–0.73) 1.87E−07
Neural cell adhesion molecule 1, 120 kDa isoform P13591 NCAM1 0.51 (0.44–0.60) 6.01E−17 0.63 (0.54–0.73) 1.10E−09
Tumor necrosis factor-inducible gene 6 protein P98066 TNFAIP6 0.51 (0.44–0.60) 2.05E−15 0.65 (0.56–0.75) 5.30E−09
Wnt inhibitory factor 1 Q9Y5W5 WIF1 0.52 (0.43–0.62) 2.39E−12 0.76 (0.66–0.88) 1.62E−04
Hepatocyte growth factor receptor P08581 MET 0.52 (0.44–0.60) 1.22E−16 0.73 (0.63–0.85) 4.76E−05
Osteomodulin Q99983 OMD 0.53 (0.45–0.62) 2.38E−14 0.75 (0.65–0.87) 1.21E−04
Transforming growth factor beta receptor type 3 Q03167 TGFBR3 0.53 (0.45–0.62) 9.27E−16 0.72 (0.62–0.84) 1.78E−05
Mast/stem cell growth factor receptor Kit P10721 KIT 0.56 (0.47–0.65) 9.54E−13 0.74 (0.64–0.86) 5.65E−05
Gelsolin P06396 GSN 0.57 (0.49–0.67) 1.83E−12 0.66 (0.57–0.76) 3.50E−08
Iduronate 2-sulfatase P22304 IDS 0.59 (0.51–0.69) 2.21E−11 0.76 (0.65–0.87) 1.70E−04
72 kDa type IV collagenase P08253 MMP2 0.60 (0.51–0.69) 2.09E−11 0.64 (0.56–0.74) 3.08E−09
Neural cell adhesion molecule L1-like protein O00533 CHL1 0.60 (0.51–0.69) 2.41E−11 0.73 (0.63–0.83) 6.26E−06
Epidermal growth factor receptor P00533 EGFR 0.60 (0.51–0.70) 7.17E−11 0.73 (0.62–0.86) 2.28E−04
Interleukin-1 Receptor accessory protein Q9NPH3 IL1RAP 0.60 (0.51–0.70) 1.61E−10 0.71 (0.62–0.82) 1.61E−06
Apolipoprotein B P04114 APOB 0.60 (0.52–0.69) 9.93E−12 0.77 (0.67–0.88) 1.66E−04
Neurogenic locus notch homolog protein 1 P46531 NOTCH1 0.61 (0.52–0.70) 4.64E−11 0.77 (0.67–0.88) 1.63E−04
Plasma protease C1 inhibitor P05155 SERPING1 0.61 (0.53–0.71) 3.89E−11 0.66 (0.56–0.77) 1.80E−07
Chordin-like protein 1 Q9BU40 CHRDL1 0.67 (0.57–0.79) 2.86E−06 0.72 (0.60–0.86) 4.50E−04
Thrombin P00734 F2 0.68 (0.57–0.81) 2.65E−05 0.65 (0.55–0.75) 4.13E−08
Kallikrein-8 O60259 KLK8 0.72 (0.62–0.83) 5.94E−06 0.79 (0.69–0.90) 4.12E−04
Superoxide dismutase [Mn], mitochondrial P04179 SOD2 0.73 (0.63–0.84) 2.42E−05 0.74 (0.64–0.85) 3.13E−05
Muellerian-inhibiting factor P03971 AMH 0.74 (0.64–0.85) 4.28E−05 0.77 (0.66–0.88) 4.05E−04
  1. All analyses were adjusted for age, sex, smoking status and physical activity
  2. OR; odds ratio per 1 SD increase in log-transformed protein levels