Fig. 6

Body weight, heart weight, fractional shortening ACE2 and genes effecting ACE2 trafficking in mice treated (db/db) with antidiabetic drugs. Metformin (Met), Dapagliflozin (DAPA), Dulaglutide (Dula) were administered concomitantly with Ang. a Body weight, b heart weight and (c) fractional shortening are shown as mean ± SEM. mRNA expression levels of (d) ACE2, (e) ACE2 (f) TMPRSS2 (g) Furin (h) ADAM10, (I) ADAM17 in db/db (db) hearts following Ang infusion and anti-diabetic drugs. Values are shown as mean ± SEM P value evaluated with paired Student’s t-test, *p < 0.05**p < 0.001vs WT #P < 0.05 vs db/db mice