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Table 3 Summary of cytokine profile changes in Zucker Obese (ZOC) rats when compared to control Zucker Lean rats (ZLC)

From: Sacubitril/valsartan inhibits obesity-associated diastolic dysfunction through suppression of ventricular-vascular stiffness

Molecule

Gene

ZOC/ZLC

log2FC

P-value

RANTES

Ccl5

− 1.288

0.050

PDGF-AA

Pdgfa

− 1.359

0.012

GFR-alpha-1

Gfra1

− 0.885

0.049

SCF

Kitl

− 0.269

0.043

IL-7

Il7

− 0.655

0.024

  1. RANTES Regulated upon Activation, Normal T Cell Expressed and Presumably Secreted, PDGF Platelet Derived Growth Factor, GFR-alpha-1 Glial Cell line-derived Neurotrophic Factor Receptor Alpha 1, SCF Stem Cell Factor, IL Interleukin
  2. Molecules on the cytokine array that showed at least log2 fold-change (log2FC) of 1.2 and with a p-value ≤ 0.05 are shown. Statistical significance between the indicated groups determined by unpaired two-tailed t-tests. Gene symbols corresponding to each cytokine are shown. Sample size: N = 4/group