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Fig. 2 | Cardiovascular Diabetology

Fig. 2

From: Sacubitril/valsartan inhibits obesity-associated diastolic dysfunction through suppression of ventricular-vascular stiffness

Fig. 2

Sacubitril/valsartan (sac/val) reduces left ventricular myocardial interstitial (a) and periarterial (b) fibrosis in ZO rats. Representative PSR stained images show fibrosis in the myocardial interstitium (a) or surrounding an arteriole (b). Accompanying bar graphs show quantitative analysis of average intensity of PSR staining in panel a and area of fibrosis normalized to arteriole diameter in panel b. Data are represented by means ± SE. N = 6, 6, 5, 5 and 7 for ZOC, ZOSV, ZOV and ZOH, respectively. Symbols: *Indicates p < 0.05 versus ZLC; †Indicates p < 0.05 versus ZOC. Scale bars = 50 µm

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Cardiovascular Diabetology

ISSN: 1475-2840