Table 1 Randomized controlled trials evaluating the effect of systematic screening of coronary artery disease in the risk of major cardiovascular adverse events in people with diabetes
Study | Population | Inclusion period | Follow-up (years) | Primary outcome | Sample size | Number of events | Expected incidence (%/year) | Observed incidence (%/year) | Hazard ratio (95% CI) |
|---|---|---|---|---|---|---|---|---|---|
Faglia et al. [16] | T2DM Age 46–75 years +\(\ge \) 2 CV risk factors | 1998–1999 | 4.5 | Major (cardiac death or MI) or minor (resting and effort angina) event | 141 | 19 | 3 | 3 | - |
DIAD [11] | T2DM Age 50–70 years | 2000–2002 | 4.8 | Non-fatal MI or CV death | 1123 | 32 | 1—2 | 0.6 | 0.88 (0.44–1.88) |
DYNAMIT [12] | DT2M Age 55–75 years +\(\ge \) 2 CV risk factors | 2000–2003 | 3.5 | All-cause death, non-fatal MI, non-fatal stroke, HH requiring hospitalization or visit to emergency department | 631 | 54 | 5.5 | 2.4 | 1.00 (0.59–1.71) |
FACTOR-64 [13] | T2DM + T1DM Men \(\ge \) 50, Women \(\ge \) 55 years diabetes duration \(\ge \) 3 years or Men \(\ge \) 40 years, Women \(\ge \) 45y + Diabetes duration \(\ge \) 5 years | 2007–2013 | 4.0 | All-cause death, nonfatal MI, or hospitalization for unstable angina | 900 | 62 | 8 | 1.7 | 0.80 (0.49–1.32) |
DADDY-D [14] | T2DM Age 50–70 years 10-year CV risk score ≥ 10% | 2007–2012 | 3.6 | Non-fatal MI or CV death | 520 | 26 | 2.6 | 1.4 | 0.85 (0.39–1.83) |