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Table 1 Randomized controlled trials evaluating the effect of systematic screening of coronary artery disease in the risk of major cardiovascular adverse events in people with diabetes

From: Cost-effectiveness of screening of coronary artery disease in patients with type 2 DIABetes at a very high cardiovascular risk (SCADIAB study) rational and design

Study Population Inclusion period Follow-up (years) Primary outcome Sample size Number of events Expected incidence (%/year) Observed incidence (%/year) Hazard ratio (95% CI)
Faglia et al. [16] T2DM
Age 46–75 years
+\(\ge \) 2 CV risk factors
1998–1999 4.5 Major (cardiac death or MI) or minor (resting and effort angina) event 141 19 3 3 -
DIAD [11] T2DM
Age 50–70 years
2000–2002 4.8 Non-fatal MI or CV death 1123 32 1—2 0.6 0.88 (0.44–1.88)
DYNAMIT [12] DT2M
Age 55–75 years
+\(\ge \) 2 CV risk factors
2000–2003 3.5 All-cause death, non-fatal MI, non-fatal stroke, HH requiring hospitalization or visit to emergency department 631 54 5.5 2.4 1.00 (0.59–1.71)
FACTOR-64 [13] T2DM + T1DM
Men \(\ge \) 50, Women \(\ge \) 55 years
diabetes duration \(\ge \) 3 years
or
Men \(\ge \) 40 years, Women \(\ge \) 45y + Diabetes duration \(\ge \) 5 years
2007–2013 4.0 All-cause death, nonfatal MI, or hospitalization for unstable angina 900 62 8 1.7 0.80 (0.49–1.32)
DADDY-D [14] T2DM
Age 50–70 years
10-year CV risk score ≥ 10%
2007–2012 3.6 Non-fatal MI or CV death 520 26 2.6 1.4 0.85 (0.39–1.83)
  1. T2DM type 2 diabetes mellitus, T1DM type 1 diabetes mellitus, CV cardiovascular, MI myocardial infarction, HH heart failure