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Fig. 8 | Cardiovascular Diabetology

Fig. 8

From: Angiotensin II-induced upregulation of SGLT1 and 2 contributes to human microparticle‐stimulated endothelial senescence and dysfunction: protective effect of gliflozins

Fig. 8

Schematic summarizing the present findings, which indicate that angiotensin II and circulating microparticles from coronary artery disease patients (CAD-MPs) via the local angiotensin system upregulate SGLT1 and SGLT2 expression to promote endothelial senescence and dysfunction in coronary endothelial cells. All of these effects are prevented by gliflozins

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Cardiovascular Diabetology

ISSN: 1475-2840