Table 4 Subgroup and sensitivity analysis
Subgroup | PS overlap weighted HR (95%CI) | |
|---|---|---|
SSE/vascular death | Major/CRNM bleeding | |
Age | ||
≥ 80 years | 0.93 (0.87–1.00) | 1.06 (0.96–1.18) |
< 80 years | 0.91 (0.86–0.96) | 0.90 (0.84–0.96) |
Sex | ||
Female | 0.94 (0.88–1.01) | 0.97 (0.89–1.06) |
Male | 0.89 (0.84–0.94) | 0.92 (0.85–0.99) |
eGFR | ||
> 50 | 0.93 (0.89–1.03) | 0.92 (0.86–0.98) |
30–50 | 0.89 (0.80–0.99) | 1.03 (0.89–1.19) |
< 30 | 0.79 (0.67–0.93) | 1.02 (0.82–1.27) |
Hemoglobin A1c | ||
≥ 8.5 | 0.86 (0.78–0.95) | 0.89 (0.77–1.03) |
< 8.5 | 0.93 (0.86–0.97) | 0.95 (0.89–1.01) |
Morbid obesity | ||
Yes | 0.89 (0.82–0.99) | 0.85 (0.75–0.95) |
No | 0.92 (0.87–0.96) | 0.97 (0.91–1.03) |
Heart failure | ||
Yes | 0.92 (0.87–0.97) | 1.02 (0.94–1.11) |
No | 0.89 (0.83–0.95) | 0.87 (0.80–0.94) |
Vascular disease | ||
Yes | 0.91 (0.85–0.97) | 1.03 (0.94–1.31) |
No | 0.89 (0.85–0.95) | 0.89 (0.82–0.95) |
Peripheral artery disease | ||
Yes | 0.92 (0.85–1.00) | 1.10 (0.98–1.23) |
No | 0.91 (0.86–0.95) | 0.90 (0.84–0.96) |
Revascularization | ||
Yes | 0.94 (0.87–1.01) | 0.99 (0.90–1.10) |
No | 0.88 (0.84–0.93) | 0.97 (0.94–1.01) |
Prior stroke | ||
Yes | 1.02 (0.93–1.13) | 0.98 (0.83–1.17) |
No | 0.89 (0.85–0.93) | 0.93 (0.88–0.99) |
Concomitant aspirin | ||
Yes | 0.92 (0.88–1.01) | 1.05 (0.97–1.30) |
No | 0.86 (0.84–0.93) | 0.86 (0.80–0.93) |
Frailty score | ||
Low | 0.86 (0.80–0.94) | 0.85 (0.77–0.94) |
Moderate-to-high | 0.92 (0.87–0.96) | 0.99 (0.92–1.05) |
Rivaroxaban dose | ||
20 mg | 0.76 (0.72–0.80)* | 0.86 (0.80–0.92) |
15 mg | 0.93 (0.88–0.99) | 0.93 (0.86–1.02) |
Warfarin time in therapeutic INR | ||
< 25% | 0.72 (0.69–0.76) | 0.64 (0.60–0.69) |
25 to < 50% | 0.72 (0.68–0.76) | 0.74 (0.69–0.79) |
50 to < 75% | 1.02 (0.97–1.08) | 1.03 (0.96–1.11) |
≥ 75% | 1.33 (1.22–1.44) | 1.67 (1.48–1.85) |
PS method | ||
OLW | 0.91 (0.88–0.95) | 0.94 (0.89–0.99) |
sIPTW | 0.94 (0.91–0.99) | 1.00 (0.92–1.08) |
1:1 PSM (caliper = 0.25 SD) | 0.89 (0.85–0.94) | 0.89 (0.83–0.95) |
2-year follow-up cap | 0.93 (0.88–0.98) | 0.98 (0.92–1.06) |