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Table 3 Results of multivariate Cox regression for incidence/progression of peripheral artery disease including aortic stiffness (carotid-femoral pulse wave velocity) and common carotid intima-media thickness into the models

From: Traditional and non-traditional risk factors for peripheral artery disease development/progression in patients with type 2 diabetes: the Rio de Janeiro type 2 diabetes cohort study

Covariates Model 1a Model 2a Model 3a
HR (95% CI) C-statistic (95% CI) HR (95% CI) C-statistic (95% CI) HR (95% CI) C-statistic (95% CI)
Separated inclusion
 cf-PWV (1 m/s increase) 1.11 (1.02–1.21) 0.725 (0.669–0.780) 1.10 (1.01–1.20) 0.745 (0.694–0.796) 1.10 (1.01–1.20) 0.738 (0.681–0.794)
 cf-PWV > 10 m/s 1.73 (1.02–2.93) 0.709 (0.654–0.762) 1.62 (0.96–2.72) 0.734 (0.684–0.783) 1.56 (0.91–2.68) 0.721 (0.663–0.779)
 CC-IMT (0.1 mm increase) 1.22 (1.04–1.44) 0.718 (0.653–0.782) 1.18 (1.00–1.38) 0.755* (0.699–0.812) 1.13 (0.95–1.34) 0.738 (0.675–0.800)
 CC-IMT > 1.05 mm 1.28 (0.72–2.26) 0.706 (0.645–0.767) 1.07 (0.61–1.90) 0.750 (0.698–0.802) 1.03 (0.57–1.88) 0.728 (0.666–0.789)
Concomitant inclusion
 cf-PWV (1 m/s increase) 1.18 (1.06–1.32) 0.732* (0.670–0.795) 1.17 (1.05–1.31) 0.762* (0.707–0.817) 1.17 (1.05–1.30) 0.751* (0.689–0.813)
 CC-IMT (0.1 mm increase) 1.16 (0.98–1.37) 1.12 (0.94–1.32) 1.08 (0.90–1.29)
 cf-PWV > 10 m/s 2.06 (1.17–3.60) 0.715 (0.656–0.775) 1.89 (1.10–3.27) 0.755* (0.704–0.807) 1.96 (1.09–3.53) 0.736 (0.673–0.800)
 CC-IMT > 1.05 mm 1.18 (0.66–2.14) 1.00 (0.55–1.81) 0.98 (0.53–1.83)
  1. Values are hazard ratios (95% confidence intervals) and C-statistics (95% confidence intervals)
  2. HR hazard ratio, CI confidence interval, cf-PWV carotid-femoral pulse wave velocity, CC-IMT common carotid intima-media thickness
  3. p < 0.01; p < 0.05
  4. *C-statistic significantly (p < 0.05) greater than those in their respective models shown in Table 2
  5. aModels 1, 2 and 3 are the same as in Table 2 with further inclusion of the aortic stiffness and carotid IMT parameters