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Table 3 Risk for myocardial infarction, coronary heart disease, stroke and peripheral artery disease following myocardial infarction

From: Risk for recurrent cardiovascular disease events among patients with diabetes and chronic kidney disease

 

Prior CVD

(n = 89,920)

Diabetes only

(n = 46,032)

CKD only

(n = 13,459)

Diabetes and CKD

(n = 13,319)

Myocardial infarction

 Number of events

14,350

5725

1894

2562

 Incidence Rate (95% CI)

84 (82, 85)

63 (62, 64)

85 (81, 89)

117 (113, 122)

Hazard ratio (95% CI)

 Model 1

1.00 (ref)

0.83 (0.80–0.85)

0.89 (0.85–0.94)

1.30 (1.24–1.35)

 Model 2

1.00 (ref)

0.88 (0.85–0.91)

0.92 (0.87–0.96)

1.25 (1.20–1.31)

Coronary heart disease

 Number of events

18,741

8055

2266

3051

 Incidence Rate (95% CI)

114 (113, 116)

92 (90, 94)

105 (100, 109)

145 (140, 150)

Hazard ratio (95% CI)

 Model 1

1.00 (ref)

0.85 (0.82–0.87)

0.86 (0.82–0.90)

1.20 (1.16–1.25)

 Model 2

1.00 (ref)

0.91 (0.88–0.94)

0.90 (0.86–0.94)

1.19 (1.14–1.24)

Stroke

 Number of events

3019

1342

401

469

 Incidence Rate (95% CI)

16 (16, 17)

14 (13, 15)

17 (15, 18)

19 (18, 21)

Hazard ratio (95% CI)

 Model 1

1.00 (ref)

0.98 (0.91–1.04)

0.87 (0.79–0.97)

1.11 (1.01–1.23)

 Model 2

1.00 (ref)

1.00 (0.93–1.08)

0.87 (0.78–0.97)

1.09 (0.98–1.20)

Peripheral artery disease

 Number of events

1238

577

104

241

 Incidence Rate (95% CI)

7 (6, 7)

6 (5, 6)

4 (3, 5)

10 (9, 11)

Hazard ratio (95% CI)

 Model 1

1.00 (ref)

0.85 (0.77–0.94)

0.65 (0.53–0.79)

1.32 (1.15–1.52)

 Model 2

1.00 (ref)

0.92 (0.83–1.03)

0.66 (0.54–0.81)

1.28 (1.11–1.49)

  1. CI confidence interval, CKD chronic kidney disease, CVD cardiovascular disease Incidence rates are presented as per 1000 person-years
  2. Model 1 includes adjustment for age, sex, race/ethnicity (for patients in the Medicare sample), geographic region of residence and area-level income (for patients in the Medicare sample)
  3. Model 2 includes adjustment for Model 1 plus smoking, hypertension, depression, history of heart failure, cardiologist care, endocrinologist care, antihypertensive medication use, statin therapy and intensity, and ezetimibe use