Clinical and metabolomic predictors of regression to normoglycemia in a population at intermediate cardiometabolic risk

Sevilla-González, Magdalena del Rocío; Merino, Jordi; Moreno-Macias, Hortensia; Rojas-Martínez, Rosalba; Gómez-Velasco, Donají Verónica; Manning, Alisa K.

doi:10.1186/s12933-021-01246-1

Cardiovascular Diabetology

Table 3 Metabolites at baseline associated with HOMA-IR and HOMA-B at follow-up

From: Clinical and metabolomic predictors of regression to normoglycemia in a population at intermediate cardiometabolic risk

Metabolites	Metabolites associated with HOMA-IR				Metabolites associated with HOMA-B
Metabolites	β	SE	CI 95%	p value	β	SE	CI 95%	p value
Phospholipids in large HDL	− 0.14	0.04	− 0.24 to − 0.04	0.003	− 0.11	0.04	− 0.20 to − 0.02	0.011
Concentration of large HDL particles	− 0.15	0.04	− 0.24 to − 0.05	0.002	− 0.11	0.04	− 0.20 to − 0.02	0.012
Total lipids in very large HDL	− 0.15	0.04	− 0.24 to − 0.05	0.002	− 0.12	0.10	− 0.20 to − 0.02	0.008
Creatinine	0.10	0.04	0.005 to 0.20	0.038	0.12	0.04	0.03 to 0.21	0.009
Mean diameter for HDL particles	− 0.12	0.04	− 0.22 to − 0.03	0.007	− 0.10	0.04	− 0.19 to − 0.01	0.021
Free cholesterol in large HDL	− 0.13	0.05	− 0.23 to − 0.03	0.008	− 0.11	0.04	− 0.21 to − 0.02	0.012
Cholesterol esters in very large HDL	0.09	0.04	0.001 to 0.19	0.04
Free cholesterol in very large HDL	− 0.15	0.04	− 0.24 to − 0.05	0.001	− 0.11	0.04	− 0.20 to − 0.02	0.012
Total cholesterol in large HDL	− 0.13	0.05	− 0.23 to − 0.03	0.008	− 0.12	0.04	− 0.21 to − 0.09	0.010
Cholesterol esters in large HDL	− 0.13	0.05	− 0.23 to − 0.03	0.008	− 0.12	0.04	− 0.21 to − 0.03
Total lipids in large HDL	− 0.12	0.05	− 0.22 to − 0.03	0.010	− 0.12	0.04	− 0.21 to − 0.02	0.010
Concentration of large HDL particles	− 0.12	0.05	− 0.22 to − 0.03	0.010	− 0.12	0.04	− 0.21 to − 0.02	0.010
Phospholipids in medium HDL	− 0.13	0.05	− 0.22 to − 0.03	0.009	− 0.12	0.04	− 0.21 to − 0.03	0.009
Total cholesterol in very large HDL	− 0.12	0.04	− 0.21 to − 0.02	0.014	–	–		–
Total cholesterol in HDL2	− 0.11	0.04	− 0.21 to − 0.02	0.016	− 0.09	0.04	− 0.18 to − 0.009	0.03
Total cholesterol in HDL	− 0.10	0.04	− 0.20 to − 0.01	0.02	− 0.09	0.04	− 0.18 to − 0.002	0.04
Free cholesterol in medium HDL	− 0.10	0.04	− 0.20 to − 0.009	0.03	–	–		–
Cholesterol esters in very large HDL	− 0.10	0.04	− 0.20 to − 0.009	0.03	–	–		–
Mean diameter for LDL particles	0.10	0.04	0.009 to 0.20	0.03	0.010	0.04	0.01 to 0.19	0.021
Free cholesterol in very large HDL	− 0.10	0.04	− 0.19 to − 0.005	0.03	–	–		–
Cholesterol esters in small VLDL	0.10	0.04	0.005 to 0.20	0.03	–	–		–
Total cholesterol in small VLDL	0.10	0.04	0.004 to 0.20	0.04	–	–		–
Triglycerides in medium HDL	0.10	0.04	0.002 to 0.19	0.04
Triglycerides in small VLDL					− 0.09	0.04	− 0.18 to − 0.001	0.04
Triglycerides in medium HDL					− 0.10	0.04	− 0.19 to − 0.01	0.02

Italic metabolites represent those associated with normal fasting glucose regression
CI 95% interval confidence, SE standard error
p values were computed with a lineal regression model considering as confounders: age, sex, body mass index, and baseline values: HOMA-IR and HOMA-B respectively

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ISSN: 1475-2840

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