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Table 4 Reclassification and discrimination statistics for clinical outcomes by plasma sST2

From: Prognostic value of soluble suppression of tumorigenesis-2 (sST2) for cardiovascular events in coronary artery disease patients with and without diabetes mellitus

Clinical outcomes Model C-index Continuous NRI,% IDI,%
Estimate (95%CI) P value Estimate (95%CI) P value Estimate (95%CI) P value
MACEs Model1 0.586(0.559–0.603)  < 0.001 REF  < 0.001 REF  < 0.002
Model1 + sST2 0.619(0.605–0.638) 17.8 (9.4–26.2) 0.9 (0.3–1.4)
Cardiac death Model1 0.746(0.703–0.789)  < 0.001 REF  < 0.001 REF  < 0.001
Model1 + sST2 0.783(0.743–0.823) 27.9 (15.9–34.5) 0.8 (0.2–1.6)
MI Model1 0.644(0.564–0.715) 0.352 REF 0.561 REF 0.721
Model1 + sST2 0.655(0.582–0.729) 15.3 (9.7–20.0) 1.2 (0.8–2.8)
Unstable angina Model1 0.583(0.561–0.608)  < 0.001 REF 0.015 REF 0.001
Model1 + sST2 0.601(0.583–0.617) 18.2 (10.4–31.4) 0.07 (0.01–0.26)
Revascularization Model1 0.575(0.545–0.596)  < 0.001 REF  < 0.001 REF  < 0.001
Model1 + sST2 0.584(0.572–0.609) 16.7 (3.9–22.3) 1.4 (0.6–1.8)
All-cause death Model1 0.642(0.594–0.701)  < 0.001 REF  < 0.001 REF  < 0.001
Model1 + sST2 0.766(0.717–0.806) 34.2 (11.8–54.7) 1.2 (0.4–1.3)