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Table 1 Clinical, echocardiographic and CMR characteristics of diabetic versus nondiabetic HFpEF patients

From: Diabetic phenotype and prognosis of patients with heart failure and preserved ejection fraction in a real life cohort

 

Nondiabetic N = 113 (62%)

Diabetic N = 70 (38%)

p-value

Age (years)

80 ± 8

76 ± 9

0.002

Female (n, %)

71 (63%)

42 (60%)

0.70

Body mass index (kg/m2)

27 ± 6

31 ± 6

0.001

NYHA III–IV (n, %)

60 (53%)

27 (39%)

0.056

Hospitalized for HF at inclusion (n,%)

73 (65%)

43 (61%)

0.53

Atrial fibrillation (n, %)

 History

78 (69%)

37 (53%)

0.028

 At inclusion

57 (50%)

26 (37%)

0.079

Ischemic cardiomyopathy (n, %)

27 (24%)

33 (47%)

0.001

Smoking (n, %)

50 (45%)

27 (39%)

0.42

Hypertension (n, %)

105 (93%)

67 (97%)

0.23

Hypercholesterolemia (n, %)

66 (59%)

49 (70%)

0.13

Sleep apneas (n, %)

8 (7%)

12 (18%)

0.032

COPD (n, %)

12 (11%)

7 (10%)

0.88

Medication

 Loopdiuretics (n, %)

73 (65%)

51 (73%)

0.25

 MRA (n, %)

19 (17%)

13 (19%)

0.76

 Beta blockers (n, %)

77 (68%)

41 (59%)

0.19

 ACE inhibitors/ARB (n, %)

78 (69%)

46 (66%)

0.64

Biology

 eGFR (ml/min/1.73m2)

58 ± 22

50 ± 24

0.026

 Hemoglobin (g/dL)

12 ± 2

11 ± 2

0.041

 NT-proBNP (pg/mL)

1937 [1040–3775]

1745 [955–3710]

0.56

 Troponin (pg/mL)

22 [13–37]

31 [17–42]

0.034

Echocardiography

 Indexed LA volume (mL/m2)

46 ± 19

45 ± 16

0.67

 LV ejection fraction (%)

62 ± 7

61 ± 8

0.35

 E wave velocity (mm/s)

91 ± 32

97 ± 26

0.23

 Septal E/e’

19 ± 9

20 ± 7

0.17

 TAPSE (mm)

19 ± 5

18 ± 5

0.40

 eSPAP (mmHg)

43 ± 11

45 ± 15

0.27

CMR

N = 94

N = 57

 

 CMR indexed LA Volume (mL/m2)

70 ± 31

62 ± 25

0.12

 CMR indexed LV EDV (mL/m2)

72 ± 18

74 ± 17

0.37

 CMR LV ejection fraction (%)

62 ± 8

62 ± 9

0.62

 CMR indexed LV mass (g/m2)

66 ± 18

71 ± 14

0.07

 CMR RV ejection fraction (%)

56 ± 8

58 ± 8

0.41

 CMR indexed RV EDV (mL/m2)

79 ± 25

83 ± 27

0.36

 ECV > 33%

34 (36%)

28 (53%)

0.05

  1. Continuous variables are expressed as mean ± 1 standard deviation (SD) and categorical variables as count and proportion. P-values are derived from independent sample t-test or Chi square test when appropriate
  2. NYHA: New York Heart Association; COPD: chronic obstructive pulmonary disease; GFR: glomerular filtration rate estimated by CKD-epi; MRA: mineralocorticoid receptor antagonist; ACE: angiotensin-converting enzyme; ARB: angiotensin II receptor blockers LV: left ventricle; LA: left atrium; TAPSE: tricuspid annular plane systolic excursion; eSPAP: estimated systolic pulmonary artery pressures; CMR: cardiac magnetic resonance; EDV: end diastolic volume; RV: right ventricle; ECV: extracellular volume estimated by T1 mapping
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Cardiovascular Diabetology

ISSN: 1475-2840