Univariate | Multivariate | |||
---|---|---|---|---|
HR (95%CI) | p value | Adjusted HR (95%CI) | p value | |
Insulin sensitivity surrogate index | ||||
TyG index | ||||
TyG ≤ 8.91 | Reference | Reference | ||
8.91 < TyG < 9.54 | 1.33 (1.09,1.61) | 0.004 | 1.58(1.33,1.88) | < 0.001 |
TyG ≥ 9.54 | 1.93 (1.61,2.32) | < 0.001 | 2.32 (1.92,2.80) | < 0.001 |
TGs/HDL-C ratio | 1.01 (0.99,1.03) | 0.675 | ||
SPISE index | 0.98 (0.93,1.03) | 0.318 | ||
Age, y | 1.03 (1.01,1.04) | < 0.001 | 1.02 (1.01,1.03) | < 0.001 |
Male gender | 1.04 (0.88.1.20) | 0.642 | ||
BMI, kg/m2 | 1.02 (1.01,1.04) | 0.046 | 0.99 (0.97,1.01) | 0.357 |
SBP, mmHg | 1.01 (0.99,1.02) | 0.546 | ||
DBP, mmHg | 0.99 (0.98,1.00) | 0.461 | ||
Medical history | ||||
Current/ex-Smoker | 0.93 (0.80,1.07) | 0.302 | ||
Duration of diabetes, years | 1.02 (1.01,1.03) | < 0.001 | 1.02 (0.99,1.03) | 0.857 |
CKD | 1.85 (1.43,2.40) | < 0.001 | ||
Stroke | 1.59 (1.35,1.87) | < 0.001 | 1.38 (1.16,1.63) | < 0.001 |
Hypertension | 1.17 (0.98,1.39) | 0.075 | ||
Dyslipidemia | 1.04 (0.90,1.21) | 0.558 | ||
Previous MI | 1.15 (0.91,1.44) | 0.243 | ||
Past PCI | 1.25 (1.04,1.50) | 0.020 | 0.87 (0.71,1.08) | 0.205 |
Medication used before admission | ||||
Antiplatelet agent | 1.25 (1.08,1.46) | 0.004 | 0.95 (0.80,1.13) | 0.542 |
ACEI/ARB | 1.09 (0.94,1.28) | 0.261 | ||
Beta-blocker | 1.20 (0.98,1.45) | 0.074 | ||
Statins | 1.15(0.96,1.38) | 0.120 | ||
Laboratory values | ||||
WBC,109/L | 1.04 (1.02,1.05) | < 0.001 | 1.03 (1.02,1.04) | < 0.001 |
Hemoglobin, g/L | 0.98 (0.97,0.99) | < 0.001 | 0.99 (0.98,1.01) | 0.776 |
Hs-CRP, mg/L | 1.02 (1.01,1.03) | < 0.001 | ||
RBG at admission, mmol/L | 1.02 (1.01,1.03) | 0.042 | ||
FPG, mmol/L | 1.05 (1.03, 1.08) | < 0.001 | ||
HbA1c, % | 1.04 (0.99,1.09) | 0.066 | ||
Albumin, g/L | 0.97 (0.95,0.99) | 0.004 | 1.01 (0.98,1.03) | 0.826 |
Creatinine, umol/L | 1.02 (1.01,1.03) | < 0.001 | ||
eGFR, ml/min/1.73m2 | 0.98 (0.96,0.99) | < 0.001 | 0.98(0.97,0.99) | 0.004 |
TC, mmol/L | 1.01 (0.95,1.09) | 0.673 | ||
TGs, mmol/L | 1.08 (1.01,1.12) | < 0.001 | ||
LDL-C, mmol/L | 1.01 (0.92,1.11) | 0.821 | ||
HDL-C, mmol/L | 0.94 (0.70,1.27) | 0.705 | ||
Echocardiography | ||||
LVEF,% | 0.97 (0.96,0.98) | < 0.001 | 0.98 (0.97,0.99) | < 0.001 |
Angiography findings | ||||
LM/three-disease | 1.39 (1.19,1.62) | < 0.001 | 1.15 (0.92,1.42) | 0.222 |
Proximal LAD | 1.38 (1.20,1.60) | < 0.001 | 1.13 (0.96,1.33) | 0.150 |
In-hospital treatment | ||||
PCI/CABG | 0.52 (0.45,0.61) | < 0.001 | 0.63 (0.53,0.74) | < 0.001 |
Antiplatelet agent | 0.67 (0.49,0.94) | 0.018 | 0.61 (0.42,0.88) | 0.008 |
ACEI/ARB | 0.77 (0.66,0.89) | 0.001 | 0.89 (0.76,1.05) | 0.167 |
Beta-blocker | 0.75 (0.64,0.88) | < 0.001 | 0.79 (0.67,0.94) | 0.009 |
Statins | 0.56 (0.47,0.68) | < 0.001 | 0.64 (0.52,0.78) | < 0.001 |
Hypoglycemic agents | ||||
Metformin | 0.86 (0.74,1.01) | 0.068 | 0.98 (0.83,1.16) | 0.804 |
Alpha-glucosidase inhibitor | 0.94 (0.81,1.08) | 0.367 | ||
Sulfonylurea | 0.85 (0.71,1.02) | 0.074 | 0.88(0.73,1.06) | 0.174 |
DPP-4i | 0.78 (0.29,2.08) | 0.619 | ||
Insulin | 1.40 (1.20,1.63) | < 0.001 | 1.13(0.96,1.33) | 0.139 |