Parameter | Placebo (n = 14) | Canagliflozin (n = 15) | Fixed effects test P value | ||||
---|---|---|---|---|---|---|---|
Visit 1 | Visit 2 | Visit 3 | Visit 1 | Visit 2 | Visit 3 | ||
Mean MNC | 167.00 ± 16.08 | 153.79 ± 16.08 | 155.09 ± 16.08 | 147.75 ± 15.54 | 145.93 ± 15.54 | 155.09 ± 15.54 | 0.71 |
Mean CD34+ve | 2527.64 ± 508.69 | 3128.79 ± 508.69 | 3157.36 ± 508.69 | 2452.07 ± 491.44 | 2031.40 ± 491.44 | 2682.93 ± 491.44 | 0.32 |
% of CD34+ve | 1.01 ± 0.19 | 1.04 ± 0.17 | 1.23 ± 0.21 | 0.94 ± 0.19 | 0.85 ± 0.22 | 0.93 ± 0.17 | 0.75 |
% of CD31+ve | 2.85 ± 0.33 | 2.47 ± 0.44 | 2.16 ± 0.43 | 2.75 ± 0.33 | 2.34 ± 0.38 | 2.58 ± 0.35 | 0.59 |
CD34+CD184 | 0.57 ± 0.09 | 0.45 ± 0.10 | 0.61 ± 0.11 | 0.43 ± 0.09 | 0.33 ± 0.10 | 0.37 ± 0.09 | 0.62 |
CFU | 10.30 ± 2.03 | 13.62 ± 2.10 | 13.61 ± 2.19 | 6.08 ± 1.95 | 7.62 ± 1.95 | 7.53 ± 1.89 | 0.82 |
SDF 10 NG | 0.20 ± 0.031 | 0.20 ± 0.031 | 0.23 ± 0.03 | 0.15 ± 0.03 | 0.15 ± 0.03 | 0.26 ± 0.03 | 0.26 |
SOD2 | 0.97 ± 0.23 | 1.45 ± 0.23 | 0.92 ± 0.24 | 1.00 ± 0.22 | 1.05 ± 0.24 | 1.36 ± 0.24 | 0.22 |
Catalase | − 0.03 ± 0.25 | − 0.09 ± 0.25 | − 0.61 ± 0.26 | − 0.55 ± 0.23 | − 0.55 ± 0.26 | 0.20 ± 0.26 | 0.04 |
GPX35 | 2.00 ± 0.54 | 2.00 ± 0.54 | 1.71 ± 0.54 | 2.00 ± 0.47 | 1.64 ± 0.50 | 2.25 ± 0.54 | 0.68 |
CXCL12 | 1.00 ± 0.16 | 0.53 ± 0.17 | 0.33 ± 0.17 | 1.00 ± 0.15 | 0.60 ± 0.16 | 0.63 ± 0.18 | 0.59 |
CXCR4 | 1.06 ± 0.17 | 1.03 ± 0.17 | 0.90 ± 0.18 | 1.00 ± 0.16 | 1.03 ± 0.18 | 1.58 ± 0.18 | 0.06 |
EDN1 | 1.22 ± 0.27 | 1.05 ± 0.29 | 1.03 ± 0.29 | 1.00 ± 0.24 | 0.79 ± 0.27 | 2.10 ± 0.27 | 0.02 |
VEGEF-A | 0.95 ± 0.17 | 1.46 ± 0.18 | 0.83 ± 0.19 | 1.00 ± 0.17 | 0.86 ± 0.18 | 1.12 ± 0.19 | 0.04 |
PECAM | 0.94 ± 0.11 | 1.43 ± 0.11 | 0.89 ± 0.12 | 1.00 ± 0.11 | 0.87 ± 0.12 | 1.28 ± 0.12 | 0.002 |
KDR | 1.00 ± 0.18 | 0.53 ± 0.18 | 0.50 ± 0.20 | 1.00 ± 0.18 | 0.55 ± 0.20 | 1.16 ± 0.20 | 0.13 |
NOS3 | 1.11 ± 0.21 | 0.06 ± 0.21 | − 0.25 ± 0.21 | 0 ± 0.18 | − 0.23 ± 0.19 | 0.34 ± 0.21 | 0.08 |
Wilm’s tumor | 6.52 ± 0.65 | 6.13 ± 0.72 | 6.36 ± 0.75 | 6.27 ± 0.60 | 6.68 ± 0.62 | 5.75 ± 0.59 | 0.45 |
Nephrin | 6.15 ± 0.55 | 5.10 ± 0.62 | 5.87 ± 0.65 | 5.39 ± 0.51 | 5.70 ± 0.53 | 5.24 ± 0.50 | 0.25 |
PODXL | 6.72 ± 0.33 | 6.08 ± 0.38 | 6.68 ± 0.40 | 7.05 ± 0.31 | 6.92 ± 0.32 | 6.62 ± 0.30 | 0.34 |