| |
ND-CAD (n = 27)
|
D-CAD (n = 20)
|
p-value
|
|---|
|
Age (year)
|
68.7 ± 1.6
|
69.2 ± 1.9
|
0.8
|
|
Gender (male/female)
|
24/3
|
13/7
| |
|
Metabolic profile
|
|
BMI (kg/m2)
|
29.3 ± 0.9
|
33.9 ± 1.1
|
0.002**
|
|
Diabetic duration (years)
|
–
|
11.3 ± 1.7
| |
|
HbA1c (mmol/mol)
|
37.1 ± 0.7
|
55.3 ± 2.5
|
< 0.001***
|
|
Hemodynamic profile
|
|
MAP (mm Hg)
|
95.0 ± 2.6
|
95.9± 2.6
|
0.81
|
|
LVEDV (mL)
|
102.0 ± 7.9
|
106.8 ± 9.9
|
0.74
|
|
LVESV (mL)
|
47.6 ± 5.7
|
59.0 ± 8.5
|
0.29
|
|
HR (beats/min)
|
73.9 ± 4.2
|
71.7 ± 2.6
|
0.68
|
|
SV (mL)
|
54.4 ± 3.0
|
47.7 ± 3.2
|
0.22
|
|
CO (L/min)
|
4.0 ± 0.4
|
3.5 ± 0.2
|
0.4
|
|
Diastolic profile
|
|
E/A
|
1.0 ± 0.1
|
0.7 ± 0.05
|
0.03*
|
|
E/e’
|
11.6 ± 0.7
|
13.1 ± 1.0
|
0.21
|
|
decT (msec)
|
245.8 ± 11.9
|
271.8 ± 19.8
|
0.24
|
|
Systolic profile
|
|
Ejection fraction (%)
|
55.3 ± 1.8
|
49.1 ± 2.0
|
0.027*
|
|
Fractional shortening (%)
|
30.6 ± 1.2
|
30.3 ± 2.6
|
0.93
|
|
Ventricular structure
|
|
IVSd (cm)
|
1.2 ± 0.1
|
1.3 ± 0.1
|
0.56
|
|
LVPWd (cm)
|
1.1 ± 0.04
|
1.0 ± 0.1
|
0.66
|
|
LVIDd (cm)
|
4.6 ± 0.1
|
4.9 ± 0.2
|
0.21
|
|
LVIDs (cm)
|
3.2 ± 0.1
|
3.4 ± 0.2
|
0.34
|
|
Medications
|
|
Statins
|
21/27 (77.8%)
|
18/20 (90.0%)
| |
|
Beta-blockers
|
20/27 (74.1%)
|
15/20 (75.0%)
| |
|
ACE inhibitors
|
11/27 (40.7%)
|
12/20 (60.0%)
| |
|
Calcium channel blockers
|
3/27 (11.1%)
|
14/20 (70.0%)
| |
|
Anti-diabetic agents
|
0/27 (0%)
|
16/20 (80.0%)
| |
|
Insulin
|
–
|
5/16 (31.3%)
| |
|
Metformin
|
–
|
5/16 (31.3%)
| |
|
Sulfonylurea
|
–
|
1/16 (6.3%)
| |
|
Insulin and metformin
|
–
|
4/16 (25.0%)
| |
|
Metformin and sulfonylurea
|
–
|
1/16 (6.3%)
| |
- BMI Body mass index, HbAIC Glycated hemoglobin, MAP Mean arterial pressure, LVEDV Left ventricular end-diastolic volume, LVESV Left ventricular end-systolic volume, HR Heart rate, SV Stroke volume, CO Cardiac output, E Early ventricular filling velocity, A Late ventricular filling velocity, e’ Early ventricular myocardium relaxation velocity, decT Early ventricular deceleration time, IVSd Interventricular septal diameter diastole, LVPWd Left ventricular posterior wall thickness at diastole, LVIDd Left ventricular internal diameter at diastole, LVIDs Left ventricular internal diameter at systole. Data are presented as mean ± SEM. Unpaired T-test was performed. *p < 0.05; **p < 0.01; ***p < 0.0001 VS ND-CAD patients
