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Table 3 Predictors of cardiovascular and all-cause mortality in type 2 diabetes mellitus patients

From: Plasma fibrin clot properties and cardiovascular mortality in patients with type 2 diabetes: a long‐term follow‐up study

Predictor HR* (95% CI) HR** (95% CI) HR*** (95% CI) HR**** (95% CI)
Cardiovascular mortality
 D-Dmax > 4.26 mg/l 5.43 (1.99–14.79) 5.79 (2.08–16.16) 5.08 (1.85–13.9) 6.85 (1.85–13.90)
 D-Drate < 0.07 mg/l/min 2.97 (1.07–8.23) 4.52 (1.47–13.86) 3.49 (1.24–9.82) 3.77 (1.33–10.69)
 Peak thrombin > 283.5 nM 5.65 (2.07–15.51) 9.23 (2.97–28.86) 6.50 (2.34–18.18) 7.10 (2.52–20.05)
All-cause mortality
 D-Dmax > 4.26 mg/l 3.48 (1.45–8.39) 3.61 (1.49–8.77) 3.45 (1.43–8.30) 3.85 (1.57–9.44)
 D-Drate < 0.07 mg/l/min 3.29 (1.31–8.28) 3.97 (1.50–10.46) 3.28 (1.03–8.24) 3.06 (1.18–7.90)
 Peak thrombin > 283.5 nM 6.54 (2.78–15.35) 9.66 (3.72–25.09) 6.69 (2.85–15.69) 7.91 (3.28–19.07)
  1. D-Dmax, D-Drate and peak thrombin were dichotomized using the cut-off value found in the receiver operating curves that optimally classified the cardiovascular and all-cause death. Data were presented as hazard ratio (HR) with 95% confidence interval (CI) calculated in multivariable Cox proportional hazards survival regression
  2. D-Dmax maximum concentration of D-dimer concentration released from the clot during lysis induced by tissue plasminogen activator, D-Drate maximum rates of increase in D-dimer levels
  3. Hazard ratios adjusted for sex and age (*); for sex, age and cardiovascular disease history (**); for sex, age and nephropathy (***); for sex, age and metformin (****)