|
Predictor
|
HR* (95% CI)
|
HR** (95% CI)
|
HR*** (95% CI)
|
HR**** (95% CI)
|
|---|
|
Cardiovascular mortality
|
|
D-Dmax > 4.26 mg/l
|
5.43 (1.99–14.79)
|
5.79 (2.08–16.16)
|
5.08 (1.85–13.9)
|
6.85 (1.85–13.90)
|
|
D-Drate < 0.07 mg/l/min
|
2.97 (1.07–8.23)
|
4.52 (1.47–13.86)
|
3.49 (1.24–9.82)
|
3.77 (1.33–10.69)
|
|
Peak thrombin > 283.5 nM
|
5.65 (2.07–15.51)
|
9.23 (2.97–28.86)
|
6.50 (2.34–18.18)
|
7.10 (2.52–20.05)
|
|
All-cause mortality
|
|
D-Dmax > 4.26 mg/l
|
3.48 (1.45–8.39)
|
3.61 (1.49–8.77)
|
3.45 (1.43–8.30)
|
3.85 (1.57–9.44)
|
|
D-Drate < 0.07 mg/l/min
|
3.29 (1.31–8.28)
|
3.97 (1.50–10.46)
|
3.28 (1.03–8.24)
|
3.06 (1.18–7.90)
|
|
Peak thrombin > 283.5 nM
|
6.54 (2.78–15.35)
|
9.66 (3.72–25.09)
|
6.69 (2.85–15.69)
|
7.91 (3.28–19.07)
|
- D-Dmax, D-Drate and peak thrombin were dichotomized using the cut-off value found in the receiver operating curves that optimally classified the cardiovascular and all-cause death. Data were presented as hazard ratio (HR) with 95% confidence interval (CI) calculated in multivariable Cox proportional hazards survival regression
- D-Dmax maximum concentration of D-dimer concentration released from the clot during lysis induced by tissue plasminogen activator, D-Drate maximum rates of increase in D-dimer levels
- Hazard ratios adjusted for sex and age (*); for sex, age and cardiovascular disease history (**); for sex, age and nephropathy (***); for sex, age and metformin (****)
