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Table 2 Association of the ESC/EASD model, NT-proBNP and SCORE with outcome in unselected patients with T2DM (n = 1690)

From: Performance of the recommended ESC/EASD cardiovascular risk stratification model in comparison to SCORE and NT-proBNP as a single biomarker for risk prediction in type 2 diabetes mellitus

 

10-years cardiovascular death

10-years all-cause death

HR [95% CI]

P

C-index [95% CI]

HR [95%CI]

P

C-index [95% CI]

ESC/EASD risk model

–

–

0.53 [0.50 to 0.56]

–

 

0.52 [0.50 to 0.54]

 Moderate

Reference

–

–

Reference

–

–

 High

23.68 [0.08–7013.72]

0.276

–

7.49 [1.04–53.94]

0.046

–

 Very high

20.88 [0.25–1747.39]

0.178

–

8.63 [1.21–61.42]

0.031

–

SCORE, %a (< 5%, 5–10%, > 10%)

–

–

0.63 [0.60–0.67]

–

–

0.62 [0.60–0.64]

 < 5%

Reference

–

–

Reference

–

–

 5–10%

3.10 [2.08–4.63]

< 0.001

–

2.90 [2.24–3.76]

< 0.001

–

 < 10%

3.79 [2.56–5.60]

< 0.001

–

3.25 [2.52–4.21]

< 0.001

–

SCORE, %

1.05 [1.04–1.07]

< 0.001

0.64 [0.60–0.67]

1.06 [1.04–1.07]

< 0.001

0.66 [0.63–0.68]

NT-proBNP, tertiles

–

–

0.75 [0.73–0.78]

–

–

0.70 [0.67–0.72]

 Tertile 1

Reference

–

–

Reference

–

–

 Tertile 2

4.24 [2.19–8.21]

< 0.001

–

1.76 [1.31–2.38]

< 0.001

–

 Tertile 3

17.21 [9.3–31.78]

< 0.001

–

4.90 [3.76–6.39]

< 0.001

–

NT-proBNP, pg/mlb

5.72 [4.68–7.00]

< 0.001

0.80 [0.77–0.83]

3.32 [2.90–3.79]

< 0.001

0.73 [0.70–0.76]

NT-proBNP, > 125 pg/ml

7.15 [4.85–10.53]

< 0.001

0.71 [0.68–0.74]

3.14 [2.56–3.86]

< 0.001

0.66 [0.63–0.68]

  1. aRefers to SCORE treated as categorical variable (cut-off: < 5%, 5–10%, > 10%)
  2. bRefers to ln-transformed NT-proBNP per 1-IQR increase