Variable | Q1 (n = 617) | Q2 (n = 622) | Q3 (n = 615) | Q4 (n = 617) | P value |
---|---|---|---|---|---|
LA volume (mL) | 26.5 ± 4.7 | 27.7 ± 5.4 | 28.6 ± 6.1 | 29.1 ± 6.2 | < 0.001 |
LA volume index (mL/m2) | 26.5 ± 4.7 | 27.7 ± 5.4 | 28.6 ± 6.0 | 29.1 ± 6.2 | < 0.001 |
Relative wall thickness (cm) | 0.42 ± 0.07 | 0.44 ± 0.07 | 0.45 ± 0.07 | 0.46 ± 0.07 | < 0.001 |
LV mass (g) | 137 ± 27 | 157 ± 30 | 169 ± 31 | 192 ± 36 | < 0.001 |
LV mass index (g/m2) | 87 ± 14 | 95 ± 15 | 99 ± 15 | 107 ± 17 | < 0.001 |
LV ejection fraction (%) | 64 ± 5 | 64 ± 4 | 64 ± 5 | 65 ± 5 | 0.326 |
Mitral inflow velocity | |||||
E, cm/s | 0.65 ± 0.13 | 0.62 ± 0.13 | 0.61 ± 0.14 | 0.60 ± 0.14 | < 0.001 |
A, cm/s | 0.65 ± 0.14 | 0.68 ± 0.14 | 0.70 ± 0.16 | 0.73 ± 0.16 | < 0.001 |
E/A ratio | 1.05 ± 0.29 | 0.95 ± 0.26 | 0.90 ± 0.23 | 0.86 ± 0.24 | < 0.001 |
DT, ms | 178 ± 34 | 184 ± 37 | 187 ± 40 | 189 ± 41 | < 0.001 |
Tissue Doppler imaging (TDI) | |||||
TDI Sm velocity (cm/sec) | 7.43 ± 1.03 | 7.34 ± 1.06 | 7.32 ± 1.13 | 7.23 ± 1.08 | 0.015 |
TDI Em velocity (cm/sec) | 7.32 ± 1.48 | 6.73 ± 1.41 | 6.46 ± 1.26 | 6.04 ± 1.27 | < 0.001 |
E/Em ratio | 9.1 ± 2.0 | 9.5 ± 2.4 | 9.7 ± 2.6 | 10.2 ± 2.6 | < 0.001 |