| | Sham + control | Sham + empa | MI + vehicle | MI + empa |
|---|
Heart rate (bpm) | 382 ± 6 | 343 ± 6 | 350 ± 7 | 336 ± 7 |
Cardiac output (ml/min) | 77 ± 2 | 65 ± 1* | 56 ± 3*,‡ | 50 ± 2*,‡ |
FS (%) | 56 ± 1 | 55 ± 1 | 21 ± 1* | 22 ± 2 |
LVIDd (mm) | 6.8 ± 0.1 | 6.6 ± 0.1 | 8.6 ± 0.2* | 8.2 ± 0.2*,† |
LVIDs (mm) | 3.0 ± 0.1 | 3.0 ± 0.1 | 6.9 ± 0.2* | 6.5 ± 0.2 |
- Data are expressed as mean ± SEM. N = 24 in sham + control and sham + empa groups; N = 23 and 25 in MI + vehicle and MI + Empa groups, respectively
- Empa empagliflozin, HR heart rate, FS fractional shortening, LVIDd left ventricular internal diameter in diastole, LVIDs left ventricular internal diameter in systole
- * p < 0.05 vs. sham control group
- †p < 0.05 vs. MI + vehicle group
- ‡p < 0.05 vs. Sham + empa
