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Fig. 5 | Cardiovascular Diabetology

Fig. 5

From: Load-independent effects of empagliflozin contribute to improved cardiac function in experimental heart failure with reduced ejection fraction

Fig. 5

Immunoblotting for cardiac proteins involved in calcium handling and contractility in Fischer F344 rats following sham surgery or left anterior descending artery ligation (MI) and treated with vehicle or empagliflozin (20 mg/kg/day) by oral gavage for 6 weeks beginning 1 week after surgery. a Serine 16 phosphorylated phospholamban (PLN). b Threonine 17 phosphorylated PLN. c Serine 473 phosphorylated Akt. d Ca2+/calmodulin-dependent protein kinase II (CaMKII). e Peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α). f SERCA2a. n = 6/group. Values are mean ± S.D. *p < 0.05, **p < 0.01, ***p < 0.001 by two-way ANOVA followed by Fisher’s least significant difference post hoc test

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