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Table 1 Patient characteristics

From: Vascular miR-181b controls tissue factor-dependent thrombogenicity and inflammation in type 2 diabetes

Patient characteristics

n = 46

Mean ± SD, median [IQR] or percentage

Correlation coefficient vs. miR-181b

p-value

Age (years)

65.6 ± 9.3

− 0.053

0.722

Female gender (%)

26.0

0.011

0.941

BMI (kg/m2)

30.6 [27.75–35.25]

0.203

0.175

Minimal fasting blood glucose (mg/dL)

93.0 [75.75–128.3]

− 0.105

0.485

Maximal fasting blood glucose (mg/dL)

197.5 [140.5–238.8]

0.146

0.332

Average fasting blood glucose (mg/dL)

139.1 [117.8–166.5]

− 0.012

0.934

HbA1c (%)

8.39 ± 1.61

0.2895

0.051

HbA1c (mmol/mol)

68.1 ± 17.7

0.2895

0.051

CRP (mg/dL)

0.40 [0.14–0.64]

− 0.051

0.733

Leukocytes (N/nL)

7.4 [6.37–9.12]

− 0.295

0.045*

Neutrophils (%)

59.4 [52.03–66.65]

− 0.318

0.031*

Monocytes (%)

6.83 ± 2.29

0.028

0.850

d-Dimers (ng/mL)

377.8 [247.4–523.5]

− 0.343

0.019*

Hemoglobin (g/dL)

14.0 ± 1.2

− 0.089

0.555

Homocysteine (µmol/L)

12.5 [10.95–17.08]

0.071

0.637

thrombocytes (N/nL)

211.9 ± 51.7

− 0.226

0.130

Triglycerides (mg/dL)

186 [110.3–271.0]

0.222

0.136

LDL cholesterol (mg/dL)

113 [88–135]

0.043

0.796

miR-181b-5p

0.169 [0.014–0.470]

1

 

hypertension (%)

100

  

CAD (%)

41.3

− 0.177

0.236

PAD (%)

26.0

− 0.096

0.521

carotid stenosis (%)

8.6

− 0.133

0.375

history of stroke (%)

10.8

− 0.249

0.094

History of myocardial infarction (%)

15.2

− 0.006

0.964

Medication

 Insulin (%)

69.5

− 0.135

0.370

 Metformin (%)

50.0

0.462

< 0.001*

 Sulfonylurea (%)

17.3

− 0.146

0.330

 Statin (%)

50.0

− 0.040

0.787

 Diuretics (%)

60.8

0.164

0.274

 ACE inhibitor (%)

47.8

0.114

0.447

 Angiotensin receptor blocker (%)

28.2

0.194

0.194

 Aldosterone antagonist (%)

8.6

− 0.017

0.908

 Calcium antagonist (%)

17.3

− 0.177

0.239

 Nitrate vasodilators (%)

13.0

− 0.034

0.822

 Acetylsalicylic acid (%)

58.7

− 0.021

0.886

 Beta-blocker (%)

50.0

0.194

0.194

  1. N = 46, shown are either Pearson or Spearman correlation coefficients for normally and not normally distributed continuous variables, respectively. For binary variables, a point-biserial correlation was performed. Values presented are mean ± SD, medians [IQR] or percentages
  2. ACE angiotensin-converting enzyme, BMI body mass index, CAD coronary artery disease, CRP c-reactive protein, HbA1c glycated hemoglobin, LDL low-density lipoprotein, MI myocardial infarction, PAD peripheral artery disease, TF tissue factor
  3. *p<0.05
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Cardiovascular Diabetology

ISSN: 1475-2840